ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Under-Urine-Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A bladder microenvironment-adaptive ceria nanozyme hydrogel enables urea-responsive intravesical chemo-immunotherapy.Bioactive materials · 2027Article
- Beyond Conventional: A Review of Phytochemical-Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mechanically Active Contractile Hydrogels for Skin Wound Repair.Gels (Basel, Switzerland) · 2026Review
- Functional hydrogel biomaterials for urological diagnosis and treatment-design strategies and application progress: a review.Journal of materials science. Materials in medicine · 2026Review
- Albumin Protects Against Cyclophosphamide-Induced Hemorrhagic Cystitis by Scavenging Acrolein and Reactive Oxygen Species.Biomolecules · 2026Article
- Under-Urine-Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The clinical management of hemorrhagic cystitis remains challenging because of persistent inflammation and bladder mucosal barrier disruption. Although intravesical therapies, such as quercetin and hyaluronic acid (HA), show potential, their efficacy is limited by rapid urinary clearance. Hydrogels offer potential as sustained-release drug carriers and protective barriers, yet designing adhesive hydrogels with optimal wet tissue adhesion, controlled degradation, and regulation of anti-inflammation remains difficult. Here it is aimed to develop a supramolecular gelatin-based hydrogel adhesive (HADA/gelatin/Ac-β-CD/quercetin, HGCQ) that combines acrylated β-cyclodextrin as a dynamic crosslinker and hydrophobic drug carrier with dopamine-functionalized HA for enhanced tissue adhesion and antioxidant functionality. The HGCQ hydrogel exhibits controlled degradation in artificial urine with sustained quercetin release over 48 h, exceptional burst pressure tolerance of up to 18.8 kPa on the bladder, and rapid hemostatic capability with a clotting time of 15 s. Crucially, HGCQ demonstrates comprehensive therapeutic effects including pro-angiogenic potential, and broad-spectrum antimicrobial efficacy, potent reactive oxygen species scavenging with a clearance of 600 µm H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.