ArticleBMC genomics2025
Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPolycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous and recalcitrant environmental pollutants generated from petroleum activities and/or biological conversion of organic materials. Environmental exposure of mosquitoes to these pollutants can potentially select resistance to insecticides used in public health for vector control. To understand the cross-resistance potentials between PAHs and pyrethroid insecticides, microsomal fractions prepared from Anopheles coluzzii mosquitoes obtained from agricultural sites and a laboratory susceptible strain, Ngousso, were tested with three major PAHs - fluorene, fluoranthene and naphthalene. Recombinant P450s previously associated with pyrethroid resistance in Anopheles gambiae (CYPs 6M2, 6Z2, 6Z3, 9J5, 6P3, 6P4, 6P5, CYP9K1) and Anopheles funestus CYP6P9a were also used to investigate metabolism of the above PAHs alongside the microsome.
resultsMicrosomes prepared from pyrethroid-resistant Anopheles coluzzii significantly (P = 0.001, r = 0.99) depleted fluorene and fluoranthene with percentage depletions of 73%±0.5 and 43%0.0 ± 2.2, respectively. A Steady-state kinetic study demonstrated that the microsome has a high affinity for fluorene with a Km and turnover of 58.69 µM ± 20.47 and 37.016 min-
conclusionThis study demonstrates that P450 monooxygenases from the malaria vectors can metabolise PAHs, highlighting the potential of these environmental pollutants selecting the P450s, driving insecticide resistance in field populations of major malaria vectors.
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