Evidence map›Paper›PMID 41204399›Full record

ArticleBMC infectious diseases2025

Long-term cardiovascular events in individuals hospitalised with COVID-19: a retrospective cohort.

Patrícia Soares, Carolina Ruivinho, Joana Silva, Maria João Lobão, Lelita Santos, Joana Paixão, Ana Rita Ramalho, Adriana Henriques, Inês Simões, Luísa Eça Guimarães and 8 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. SARS-CoV-2 and reproductive system: a scientometric study.Frontiers in reproductive health · 2026
    Article
  3. Estimation of the Burden of Ischemic Heart Disease in the Tabasco Population, Mexico, 2013-2021.International journal of environmental research and public health · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Patrícia SoaresNational Institute of Health Doutor Ricardo Jorge, Avenida Padre Cruz, Lisbon, 1600-560, Portugal. patseraos@gmail.com.
Carolina RuivinhoNOVA National School of Public Health, Public Health Research Center, NOVA University Lisbon, Lisbon, Portugal.
Joana SilvaIndependent Occupational Health Doctor, Lisbon, Portugal.
Maria João LobãoNOVA National School of Public Health, Public Health Research Center, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, Lisbon, Portugal.
Lelita SantosServiço de Medicina Interna, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.
Joana PaixãoServiço de Medicina Interna, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.
Ana Rita RamalhoServiço de Medicina Interna, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.
Adriana HenriquesServiço de Medicina Interna, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.
Inês SimõesHospital Terras Do Infante, Centro Hospitalar Universitário Do Algarve, Lagos, Algarve, Portugal.
Luísa Eça GuimarãesServiço de Medicina Interna, Centro Hospitalar Póvoa de Varzim-Vila Do Conde, EPE, Póvoa de Varzim, Portugal.
Rita MoçaServiço de Medicina Interna, Centro Hospitalar Póvoa de Varzim-Vila Do Conde, EPE, Póvoa de Varzim, Portugal.
Andreia CostaServiço de Medicina Interna, Centro Hospitalar de Trás-Os-Montes E Alto Douro, Vila Real, Portugal.
Gabriel AtanásioServiço de Medicina Interna, Centro Hospitalar Tondela/Viseu, EPE, Viseu, Portugal.
Sofia NóbregaHospital Central Do Funchal, Serviço de Saúde da Região Autónoma da Madeira, SESARAM, Funchal, EPE, Portugal.
Maria da Luz BrazãoHospital Central Do Funchal, Serviço de Saúde da Região Autónoma da Madeira, SESARAM, Funchal, EPE, Portugal.
Ana Rita GoesNOVA National School of Public Health, Public Health Research Center, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, Lisbon, Portugal.
Andreia LeiteNational Institute of Health Doutor Ricardo Jorge, Avenida Padre Cruz, Lisbon, 1600-560, Portugal.
LOCUS group

Funding

Fundação para a Ciência e a Tecnologia,Portugal CEECINST/00049/2021/CP2817/CT0001Pfizer Portugal #68639655
6 · The paper itself

Abstract

backgroundPost-COVID condition encompasses a spectrum of persistent or emerging symptoms affecting multiple organ systems, including a heightened risk of cardiovascular complications. Despite growing recognition of this phenomenon, there remains a lack of comprehensive data regarding the incidence and risk factors associated with cardiovascular events during the post-acute phase in patients previously hospitalised for COVID-19. Thus, we aimed to estimate the incidence of cardiovascular events among patients hospitalised for COVID-19 in Portugal and assess the association between patient and infection characteristics and cardiovascular events in the COVID-19 post-acute phase.

methodsWe conducted a registry-based retrospective cohort study from seven hospitals across Portugal. Data was retrospectively collected from the electronic medical record of each patient. We included individuals hospitalised due to COVID-19 between March 2020 and March 2021. Our outcome of interest was cardiovascular events in the post-acute phase of COVID-19, occurring at least 30 days after a positive SARS-CoV-2 test. The variables of interest considered were the severity of the episode, existing cardiovascular risk and vaccination status before the SARS-CoV-2 test. Person-years was estimated for each individual, and incidence rates were estimated. A Cox proportional hazard regression model was employed to assess risk factors.

resultsWe included 1,803 patients in the analysis, of which 143 (7.9%) experienced at least one cardiovascular event following COVID-19 hospitalisation. The overall incidence rate of having at least one cardiovascular event was 34.65 per 1,000 person-years (95% confidence interval (CI): 29.20; 40.82). We found higher risk of cardiovascular events for individuals with pre-existing cardiovascular risk (adjusted hazard ratio (aHR): 3.76, 95% CI: 1.53; 9.24) and lower risk for individuals with at least one vaccine dose before the SARS-CoV-2 test (partial vaccination - aHR: 0.44, 95%CI: 0.30; 0.64, complete vaccination - aHR: 0.46, 95%CI: 0.2; 0.80). We did not find a significant difference between the severity of the COVID-19 episode and the risk of having cardiovascular events post-COVID-19.

conclusionOur findings suggest a substantial burden of cardiovascular complications post-COVID-19, underscoring the need for health services to be prepared and commence screening and preventive measures for individuals at higher risk.

Indexed as

Cardiovascular DiseasesCOVID-19AdultAgedAged, 80 and overFemaleHospitalizationHumansIncidenceMaleMiddle AgedPortugalRetrospective StudiesRisk FactorsSARS-CoV-2Cardiovascular diseasesCOVID-19 vaccinesPost-acute COVID-19 syndrome

Identifiers

PMID41204399
PMCPMC12595706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.