Evidence map›Paper›PMID 41204300›Full record

ArticleBMC public health2025

Bilateral association between muscle strength and depression: evidence from a prospective cohort study.

Tong Guo, Fanchao Meng, Sixiang Liang, Guangwei Zhao, Jun Liu, Xue Wang, Ling Zhang, Gang Wang

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Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Tong Guo *Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. guotong@mail.ccmu.edu.cn.
Fanchao Meng *Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Sixiang LiangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Guangwei ZhaoBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Jun LiuBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Xue WangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Ling ZhangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Gang WangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. gangwangdoc@ccmu.edu.cn.

Funding

2023 Sprout Science and Technology Innovation Fund by Beijing Anding Hospital, Capital Medical University No. 13-2024Beijing Anding Hospital Science Foundation No. 12-2024STI2030-Major Projects 2021ZD0200600
6 · The paper itself

Abstract

backgroundBoth low muscle strength and depressive symptoms are common among middle-aged and older adults. However, their bilateral association has not been thoroughly investigated. This study examined whether muscle strength and depression are bilaterally associated using data from a prospective cohort in China.

methodsA total of 6,961 participants without depression and 6,817 participants without low muscle strength from the China Health and Retirement Longitudinal Study were included to investigate the association of muscle strength with depression and of depressive symptoms with low muscle strength, respectively. The 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) was used to assess depressive symptoms, with a cut-off score of 10. Handgrip strength and the time taken to complete the Five Times Sit-to-Stand Test (5TSTS) were used to evaluate muscle strength. Cox regression was applied to assess the associations after adjusting for relevant variables. Restricted cubic splines (RCS) were used to explore potential non-linear relationships.

resultsThere was a significant association between handgrip strength (HR: 0.98; 95% CI: 0.98-0.99) and time of 5TSTS (HR: 1.02; 95% CI: 1.01-1.03) with the 7-year incident depressive symptoms. Similarly, depressive symptoms were significantly associated with the 4-year incident low muscle strength, as defined by both handgrip strength (HR: 1.04; 95% CI: 1.02-1.05) and time of 5TSTS (HR: 1.02; 95% CI: 1.01-1.04). No evidence of non-linear associations was detected. LIMITATION: Depressive symptoms were assessed using the CESD-10 scale rather than a clinical diagnosis.

conclusionsA bilateral longitudinal association exists between muscle strength and depression.

Indexed as

DepressionMuscle StrengthAgedChinaFemaleHand StrengthHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesBilateral associationCox regressionDepressionMuscle strengthProspective cohort

Identifiers

PMID41204300
PMCPMC12595721

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