Evidence map›Paper›PMID 41204286›Full record

Trial reportJournal of translational medicine2025

Effects of a two-week modified ketogenic diet on circulating lipoprotein subclasses, GDF15, and FGF21 in obese adults.

Nana Zhang, Na Liu, Guoxia Zhao, Juan Yan, Pinghua Zhang, Xiaomiao Li, Jie Zhou

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nana Zhang *Department of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Na Liu *Department of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Guoxia Zhao *Department of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Juan YanDepartment of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Pinghua ZhangDepartment of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xiaomiao LiDepartment of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. xiaomiao@fmmu.edu.cn.
Jie ZhouDepartment of Endocrinology and Metabolism, Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. zhoujie@fmmu.edu.cn.ORCID 0000-0002-9711-4316

Funding

Instituto Nacional de Ciência e Tecnologia Centro de Estudos das Adaptações da Biota Aquática da Amazônia 2024XJSY08Key Research and Development Projects of Shaanxi Province 2024SF2-GJHX-70Xijing Medical Personnel Development Booster Initiative XJZT25QN19
6 · The paper itself

Abstract

backgroundAs key metabolic regulators, the roles of GDF15 and FGF21 in mediating the effects of modified ketogenic diet (MKD) on weight loss and lipoprotein remodeling in obese patients require further investigation. PATIENTS AND

methodsThis study enrolled 30 metabolically healthy obese participants (BMI ≥ 28 kg/m²) for a 2-week MKD intervention. Using a self-controlled pre-post design, we performed measurements including body composition analysis, fasting serum GDF15 and FGF21 levels measurement, and serum lipoprotein subclass quantification at both baseline and post-intervention time points.

resultsFollowing a 2-week MKD intervention, participants exhibited statistically significant reductions in body weight (96.14 ± 27.23 kg vs. 91.63 ± 26.47 kg; Δ4.8%, P < 0.001) and BMI (33.99 ± 6.08 kg/m

conclusionThe short-term MKD intervention significantly improved adiposity metrics while elevating GDF15 and reducing FGF21 levels. These rapid metabolic adaptations induced potentially beneficial remodeling of HDL-c subclasses, highlighting novel effects beyond conventional lipid ratios.

trial registrationChiCTR, ChiCTR2300071823. Registered 25 May 2023 - Prospective Registered, https://www.chictr.org.cn/bin/project/edit?pid=198176 .

Indexed as

Diet, KetogenicFibroblast Growth FactorsGrowth Differentiation Factor 15LipoproteinsObesityAdultBody CompositionFemaleHumansMaleMiddle AgedFGF21 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsGDF15 protein, humanGrowth Differentiation Factor 15LipoproteinsFibroblast growth factor 21Growth differentiation factor 15Ketogenic dietLipoprotein subclassesObesity

Identifiers

PMID41204286
PMCPMC12595818

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.