ArticleBMC veterinary research2025
The effects of leukocyte
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction: The effects of leukocyteBMC veterinary research · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
backgroundCanine parvovirus (CPV) is a highly contagious virus that can lead to severe clinical complications in dogs. RNA-binding proteins (RBPs) play a crucial role in regulating translation and stabilizing RNA. Due to the failure of the immune system to respond effectively in dogs infected with CPV, this study aimed to investigate various immunological markers in CPV-infected dogs and to evaluate the impact of RBPs from these infected dogs on immune responses. Blood samples were collected from both healthy and parvovirus-infected dogs. Parvovirus infection was confirmed using immunochromatographic kits. Monocytes were isolated, and exosomes were extracted from these cells and other leukocytes. RBPs were isolated from the leukocytes of parvovirus-infected dogs using Fe-nanoparticles conjugated to RNA. The delivery of RBPs into monocytes and leukocytes was achieved through exosomes. Subsequently, the activities of anti-protease, lysozyme, myeloperoxidase, survival rates, and the expression some of the inflammatory response genes were assessed in the recipient cells.
resultsDogs with acute CPV exhibited significantly lower specific antibody titers and comparable total immunoglobulin levels, along with reduced lysozyme and myeloperoxidase activities in their leukocytes compared to asymptomatic dogs. A significant effect of exosomes and RBPs were observed on lysozyme activity, myeloperoxidase levels, and leukocyte survival. The expression of interferon-gamma (IFN-γ) (16.4-fold) and NOX2 (7.61-fold) was significantly elevated in monocytes treated with RBPs compared to untreated cells. Additionally, no viral proteins were found in RBPs extracted from infected animals.
conclusionsThe RBPs from infected dogs demonstrated a compensatory role in regulating immune responses in infected animals, rather than mediating immune regulation by CPV through RBPs. These findings enhance our understanding of the immune response alterations in dogs affected by parvovirus infection, the role of RBPs in this process, and the potential development of novel therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.