Evidence map›Paper›PMID 41204221›Full record

Observational studyCritical care (London, England)2025

Persistent inspiratory muscle weakness among extubated patients after prolonged intubation is frequent and can be predicted early by maximal inspiratory pressure measured 12 days after its initial diagnosis: a prospective observational study.

Valentin Oestreicher, Marius Hennemann, Roger Hilfiker, Thibault Faivre, Greg Zoni, Marianne Demont, Mélanie Teixeira, Roberto Ucchino, Didier Tassaux, Lise Piquilloud and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valentin Oestreicher *Care directorate, University Hospital of Geneva (HUG), Geneva, Switzerland. valentin.oestreicher@hug.ch.
Marius Hennemann *University of Applied Sciences and Arts Western Switzerland (HES-SO), Delémont, Switzerland.
Roger HilfikerPhysiotherapy Tschopp & Hilfiker, Brig, Switzerland.
Thibault FaivreAcute Medicine Department, Intensive Care Unit, University Hospital of Geneva (HUG), Geneva, Switzerland.
Greg ZoniPhysiotherapy Department for the Departments of Surgery, Cardiovascular Surgery, and Interdisciplinary Centres, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Marianne DemontPhysiotherapy Department for the Departments of Surgery, Cardiovascular Surgery, and Interdisciplinary Centres, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Mélanie TeixeiraIntensive Care Medicine Department, Hospital Network of Neuchâtel (RHNe), Neuchâtel, Switzerland.
Roberto UcchinoCritical Care Medicine Department, Hospital of Riviera - Chablais (HRC), Hospital Centre of Rennaz, Rennaz, Switzerland.
Didier TassauxAcute Medicine Department, Intensive Care Unit, University Hospital of Geneva (HUG), Geneva, Switzerland.
Lise Piquilloud *Adult Intensive Care Unit, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Olivier Contal *University of Applied Sciences and Arts Western Switzerland (HES-SO), Delémont, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProlonged mechanical ventilation (MV) frequently results in inspiratory and peripheral muscle weakness, impairing recovery. These conditions can be identified at the bedside using respectively Maximal Inspiratory Pressure (MIP) measurement and Medical Research Council (MRC) score. This study investigated the evolution over the acute-care hospital stay of MIP and MRC score in patients with documented post-extubation inspiratory muscle weakness (IMW), defined as MIP ≤ 30 cmH

methodThis exploratory prospective observational study was conducted across five Swiss hospitals. Patients in the Intensive Care Unit (ICU) who were extubated after ≥ 7 days of MV, with IMW diagnosed within 48 h post planned extubation, were included. Patients' characteristics and ICU-related factors were recorded throughout the acute care stay as were MIP and MRC score. ICU-acquired weakness (ICU-AW) recorded in the medical file, ICU readmission, reintubation, and hospital mortality were also documented. Descriptive statistics and linear interpolation for missing MIP data were applied, and associations with persistent IMW (MIP ≤ 30 cmH

resultsSixty-nine patients (48 men, 21 women) completed the study. At study completion, persistent IMW was observed in 30 patients (43%), with a median MIP of 22 [13-24] cmH

conclusionPersistent IMW following prolonged MV is frequent throughout the acute care stay and until acute care hospital discharge. The MIP measured at day 12 after inclusion, as well as its change from inclusion to day 12, were strongly associated with persistent IMW.

Indexed as

Airway ExtubationIntubation, IntratrachealMaximal Respiratory PressuresMuscle WeaknessAgedFemaleHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedProspective StudiesRespiration, ArtificialRespiratory MusclesSwitzerlandTime FactorsInspiratory muscle weaknessIntensive careIntensive care unit acquired weaknessMaximal inspiratory pressurePeripheral muscle weaknessProlonged mechanical ventilation

Identifiers

PMID41204221
PMCPMC12595635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.