Observational studyBMC geriatrics2025
Factors influencing thrombocytopenia in geriatric patients in the intensive care unit: a retrospective observational study.
Observational study in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Determinants of thrombocytopenia in critically ill patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThrombocytopenia (TP) has been associated with poor clinical outcomes in geriatric patients in the intensive care unit (ICU). However, the factors leading to TP in critically ill older patients are not clear. In this study, we aimed to investigate the primary factors influencing TP in geriatric patients in the ICU, as well as to evaluate the relationship between TP and adverse clinical outcomes.
methodsBetween 2010 and 2020, 5,848 geriatric patients were initially admitted to the ICU at Dongyang People's Hospital, with 3,147 ultimately included in the study. Lasso regression was used to screen for relevant variables, followed by multivariate logistic regression analysis. Propensity score matching (PSM) was used to further assess the impact of TP on in-hospital mortality. Validation of findings was conducted using the Medical Information Mart for Intensive Care database.
results32.6% of geriatric ICU patients developed TP during their stay. Compared with the non-TP group, the TP group showed significant increases in disease severity, hormone use, vasoactive drug use, and sepsis rates, as well as in-hospital mortality, mechanical ventilation use, duration of ICU stay, and hospitalization costs (p < 0.001). Lasso regression screening identified 24 relevant variables, and 32.6% of patients developed TP during their ICU stay. Sensitivity analyses and PSM confirmed a strong association between TP and increased in-hospital mortality.
conclusionsTP is common among geriatric patients in ICU and is associated with poor prognosis. This study identified several important factors influencing TP, highlighting valuable implications for the early identification of high-risk patients and the development of individualized treatment strategies.
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