Evidence map›Paper›PMID 41204193›Full record

ArticleBMC cancer2025

Tumor index predicts recurrences of patients with pathological stage Ⅰ gastric cancer after radical surgical resection.

Yijia Lin, Huaxian Chen, Chengzhi Wei, Dandong Luo, Jianping Guo, Xiansheng Hu, Yinghan Chen, Junsheng Peng, Yongming Chen, Lei Lian

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yijia Lin *Department of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Huaxian Chen *Department of Thyroid Surgery, Sun Yat-sen Memorial Hospital, Sun Yat- sen University, Guangzhou, China.
Chengzhi Wei *Department of Gastric Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Dandong LuoDepartment of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jianping GuoDepartment of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiansheng HuDepartment of Coloproctology, Foshan Hospital of TCM, Foshan, China.
Yinghan ChenThe Second Clinical College, Guangzhou Medical University, Guangzhou, China.
Junsheng PengDepartment of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yongming ChenDepartment of Gastric Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China. chenyongm@sysucc.org.cn.
Lei LianDepartment of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. lianlei2@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-8895-7792

Funding

National Natural Science Foundation of China 82405397Postdoctoral Fellowship Program of CPSF GZC20233247Program of Guangdong Provincial Clinical Research Center for Digestive Diseases 2020B1111170004
6 · The paper itself

Abstract

backgroundDespite the favorable prognosis of patients with pathological stage I gastric cancer (GC), recurrence may occur in a subset of individuals, and the underlying risk factors are currently being investigated. Tumor index (TI) plays a valuable role in predicting the prognosis of GC. The study aimed to determine the prognostic effect of TI on stage Ⅰ GC.

methodsPatients with stage Ⅰ GC who underwent radical resection were enrolled from the two medical centers from 2010 to 2020. TI was calculated by the pathological T stage multiplied by the maximum tumor diameter. The primary outcome was disease-free survival (DFS) and overall survival (OS). Cox regression analyses were utilized to evaluate the correlation between TI and prognosis.

resultsThe final analysis included a total of 684 patients from two medical centers. Higher TI exhibited a significant correlation with several clinicopathologic features, including N0 stage, TNM stage ⅠB, and positive PNI (all P < 0.05). Patients with high TI showed inferior DFS and OS compared to those with a low TI (P < 0.05). Multivariate analysis revealed that TI was an independent prognostic factor for DFS (hazard ratio (HR) = 2.44, P = 0.010) and OS (HR = 2.39, P = 0.014) in patients with stage Ⅰ GC who underwent radical resection.

conclusionTI was an independent risk factor in recurrence and overall survival for stage Ⅰ GC patients who received curative gastrectomy. Incorporation of TI into clinical decision-making regarding adjuvant therapy and intensity of follow-up may be warranted.

Indexed as

GastrectomyNeoplasm Recurrence, LocalStomach NeoplasmsAdultAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesRisk FactorsPrognosisRecurrenceStage ⅰ gastric cancerTumor index

Identifiers

PMID41204193
PMCPMC12595727

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