Evidence map›Paper›PMID 41204176›Full record

Observational studyBMC geriatrics2025

Unraveling the intertwined threads of insomnia and sarcopenia in cognitive and functional impairment in octogenarians.

Elias Rocha de Azevedo Filho, Cristiane Koeche, Flavia Fagundes Bueno, Otávio de Toledo, Vicente Paulo Alves, Henrique Salmazo da Silva, Clayton Franco Moraes, Wladimir M Freitas, Alessandra M Campos-Staffico, Luiz Sergio Fernandes de Carvalho

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02366104 (Brasília Study on Healthy Aging), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02366104 completednot on this map

Brasília Study on Healthy Aging

TypeobservationalSponsorUniversity of Campinas, BrazilRan2008 to 2016Enrolled230ConditionsHealthy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elias Rocha de Azevedo FilhoDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil.
Cristiane KoecheDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil.
Flavia Fagundes BuenoDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Otávio de ToledoSchool of Medicine, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Brasília, DF, Brazil.
Vicente Paulo AlvesDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil.
Henrique Salmazo da SilvaDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil.
Clayton Franco MoraesDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil.
Wladimir M FreitasBiocardios Institute, Brasília, DF, Brazil.
Alessandra M Campos-StafficoDepartment of Pharmacyl Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA.
Luiz Sergio Fernandes de CarvalhoDepartment of Gerontology, Catholic University of Brasília, Brasília, DF, Brazil. luiz.carvalho@p.ucb.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough insomnia and sarcopenia may seem unrelated in the context of older adult health, recent evidence has revealed shared underlying pathophysiological pathways. However, the extent to which these two factors jointly impact crucial clinical outcomes still needs to be determined. This study aimed to elucidate the associations of insomnia and sarcopenia with cognitive dysfunction and functional impairment, shedding light on potential mechanistic connections.

methodsIn this observational study, we scrutinized data collected from 493 individuals aged ≥ 80 years between 2016 and 2018. Sarcopenia was assessed using the EWGSOP2 criteria, insomnia was assessed using the Insomnia Severity Index, functional status was assessed using the Instrumental Activity of Daily Living Scale, and cognition was assessed using the Montreal Cognitive Assessment (MoCA). The baseline assessments included blood lipid, IFN-γ, IL-2, IL-4, IL-6, IL-10, and CRP levels and DNA methylation.

resultsInsomnia alone was not associated with cognitive impairment or functional dependence. However, sarcopenia alone increased the odds of cognitive dysfunction by a factor of 2.6 (95% confidence interval [CI] 1.2-5.6, p = 0.011), although it did not impact functional impairment. When examined together, insomnia and sarcopenia were associated with 4.8-fold increased odds of cognitive impairment (95% CI 2.1-10.9, p < 0.001) and 7.1-fold increased odds of functional impairment (95% CI 1.7-29.0, p = 0.007) compared to those with neither condition. Lipid profiles and inflammatory marker levels did not differ, but sarcopenic individuals had significantly greater DNA methylation (p < 0.001). We observed a positive multiplicative interaction between insomnia and sarcopenia on continuous MoCA scores, with a statistically significant synergy index and consistent interaction metrics.

conclusionsInsomnia and sarcopenia synergistically increase the risk of cognitive dysfunction among long-lived older adults. Sarcopenia alone impacted cognition in individuals, which could be related to the increase in inflammation-independent DNA methylation observed among individuals with sarcopenia.

trial registrationClinical Trial Number. NCT02366104.

Indexed as

Activities of Daily LivingCognitive DysfunctionFunctional StatusSarcopeniaSleep Initiation and Maintenance DisordersAged, 80 and overFemaleHumansMaleCognitive dysfunctionFunctional impairmentInsomniaLong-lived elderly individualsSarcopenia

Identifiers

PMID41204176
PMCPMC12595712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.