ArticleBMC anesthesiology2025
Effectiveness and safety of low-dose intraoperative tranexamic acid in cardiac surgery: a retrospective before-and-after study.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Aortic Arch and Frozen Elephant Trunk Surgery: Anesthetic Challenges and Strategies for Organ Protection.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranexamic acid (TXA) is widely used to reduce perioperative bleeding and transfusion requirements; however, its optimal dosing, efficacy, and safety remain uncertain, particularly in cardiac surgery patients.
methodsThis single-center, retrospective before-and-after study consecutively included adult patients who underwent cardiac and/or thoracic aortic surgery with cardiopulmonary bypass between 2011 and 2024. Patients were categorized into the before-TXA and after-TXA groups based on the implementation of a routine intraoperative low-dose TXA protocol in December 2017. This protocol included a loading dose (5 mg/kg) drawn from a 500 mg ampoule and administered at anesthesia induction, with the remaining dose added to the CPB priming volume. A maintenance infusion was administered at 5 mg/kg/h throughout surgery. The primary outcome was chest tube output during the first 12 h after surgery. Secondary safety outcomes included thrombotic complications and postoperative seizures. Outcomes were compared using interrupted time series analysis after stabilized inverse probability of treatment weighting.
resultsA total of 4,425 patients were analyzed (2,131 in the before-TXA group and 2,294 in the after-TXA group). The median (interquartile range) chest tube output during the first 12 h postoperatively was 480 mL (270-860 mL) in the before-TXA group and 400 mL (230-710 mL) in the after-TXA group. In the interrupted time series analysis, the intercept of log-transformed monthly chest tube output significantly decreased after TXA implementation (β
conclusionsThe routine implementation of low-dose intraoperative TXA in cardiac surgery was associated with a significant reduction in bleeding after cardiac surgery, without an increased risk of thrombotic complications or seizures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.