Evidence map›Paper›PMID 41204020›Full record

ArticleGeroScience2026

Germline regulation of the intestinal mitochondrial unfolded protein response.

Anna C Foulger, Nathaniel A Jordan, Alyssa Castle, Dipa Bhaumik, Julie K Andersen, Gordon J Lithgow, Suzanne Angeli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna C FoulgerBuck Institute for Research On Aging, Novato, CA, 94945, USA.ORCID http://orcid.org/0000-0003-4135-9741
Nathaniel A JordanUniversity of Maine, Orono, ME, 04469, USA.ORCID http://orcid.org/0009-0004-5441-6164
Alyssa CastleUniversity of Maine, Orono, ME, 04469, USA.ORCID http://orcid.org/0009-0007-7471-1146
Dipa BhaumikBuck Institute for Research On Aging, Novato, CA, 94945, USA.
Julie K AndersenBuck Institute for Research On Aging, Novato, CA, 94945, USA.ORCID http://orcid.org/0000-0003-1324-4875
Gordon J LithgowBuck Institute for Research On Aging, Novato, CA, 94945, USA.ORCID http://orcid.org/0000-0002-8953-3043
Suzanne AngeliUniversity of Maine, Orono, ME, 04469, USA. suzanne.angeli@maine.edu.ORCID https://orcid.org/0000-0002-6229-9648

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIGMS INBRE Research Project Subaward P20GM103423-23NIGMS INBRE Research Project Subaward P20GM103423-24NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318NIH HHS P40 OD010440
6 · The paper itself

Abstract

The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of this theory, we previously identified that pharmacological inhibition of the germline has widespread protective cell non-autonomous effects on cellular protein homeostasis in the model organism Caenorhabditis elegans. However, the cell non-autonomous effects of the germline on mitochondrial protein homeostasis are not well defined. Here, we use pharmacological or genetic inhibition of the germline to determine its effects on intestinal mitochondrial protein homeostasis as measured by the mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegansGerm CellsIntestinal MucosaMitochondriaUnfolded Protein ResponseAnimalsCaenorhabditis elegans ProteinsDeoxyuridineIntestinesMale5-fluoro-2'-deoxyuridineCaenorhabditis elegans ProteinsDeoxyuridineCaenorhabditis elegansCell non-autonomousFertilizationGermlineIntestinesMitochondrial unfolded protein responseReproduction

Identifiers

PMID41204020
PMCPMC13574745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.