SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Micronutrient requirements for stem cell transplantation patients > 100 days after transplant and during graft versus host disease: a systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere are no clinical guidelines for micronutrient supplementation and monitoring during the post-acute phase of Stem cell transplantation (SCT) and during graft versus host disease (GVHD). Hence this comprehensive systematic review aimed to evaluate the evidence for vitamin and mineral supplementation and monitoring to inform clinical practice.
methodsEligible studies included adults who had undergone SCT more than 100 days ago or were experiencing GVHD and were prescribed a micronutrient supplement and/or had micronutrient levels monitored. Human studies published in English were retrieved from five databases (Embase, Medline, Scopus, Web of Science, and CINAHL) on the 24th of May 2024. The risk of bias and certainty of evidence were assessed through the Academy of Nutrition and Dietetics Quality Criteria Checklist and The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. No meta-analysis was completed as part of this systematic review.
resultsSixteen studies (n = 1573) met eligibility criteria for inclusion. Micronutrients examined by these studies were vitamin D, calcium, and vitamin A. All studies had a neutral risk of bias. Studies reported variable prevalence of vitamin D deficiency, with mixed results regarding the association between vitamin D or calcium and the outcomes of reduced bone mineral density (BMD), chronic GVHD, mortality, sarcopenia, or fractures. The GRADE certainty of evidence for vitamin D or calcium and BMD was very low.
conclusionThe impact of micronutrient supplementation on clinical outcomes is unclear, however, monitoring vitamin D levels and calcium intake after SCT should be considered to detect deficiency or inadequate intake.
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