Evidence map›Paper›PMID 41204003›Full record

ArticleLeukemia2025

Cyclin D1 rearranged diffuse large B-cell lymphoma-an evolving concept.

K S Kurz, A Zamo, C Drewes, E Madej, C Laurent, B Burroni, M Donzel, L Xerri, L Mescam, L Plank and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

K S KurzRobert Bosch Krankenhaus, Department of Clinical Pathology, Stuttgart, Germany.
A ZamoJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.ORCID 0000-0001-6203-7966
C DrewesUlm University and Ulm University Medical Center, Institute of Human Genetics, Ulm, Germany.ORCID 0009-0008-5160-4732
E MadejUniversity of Cambridge, Department of Pathology, Cambridge, UK.ORCID 0000-0002-0729-0245
C LaurentCentre Hospitalier Universitaire (CHU) Toulouse, Institut Universitaire du Cancer-Oncopole de Toulouse, INSERM U1037, Toulouse, France.ORCID 0000-0002-5375-7512
B BurroniGHU Paris Centre-Cochin, AP-HP, Department of Pathology, Paris, France.
M DonzelHospices Civils de Lyon, Centre hospitalier Lyon Sud, Service de Pathologie Multisîte, Pierre-Bénite, France.
L XerriCRCM, INSERM, CNRS, Aix-Marseille University, Institut Paoli-Calmettes, Marseille, France.
L MescamCRCM, INSERM, CNRS, Aix-Marseille University, Institut Paoli-Calmettes, Marseille, France.
L PlankJessenius Medical Faculty of Comenius University and University Hospital, Department of Pathological Anatomy, Martin, Slovakia.
L M R GjerdrumUniversity of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark.ORCID 0000-0003-4377-3209
J GeyerWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, New York, USA.ORCID 0000-0002-4424-6139
J RichterUniversity Hospital Schleswig-Holstein, Christian Albrechts Universität Kiel, Department of Pathology, Hematopathology Section and Lymph Node Registry, Kiel, Germany.ORCID 0000-0002-9543-4084
I OschliesUniversity Hospital Schleswig-Holstein, Christian Albrechts Universität Kiel, Department of Pathology, Hematopathology Section and Lymph Node Registry, Kiel, Germany.ORCID 0000-0002-4003-6855
W KlapperUniversity Hospital Schleswig-Holstein, Christian Albrechts Universität Kiel, Department of Pathology, Hematopathology Section and Lymph Node Registry, Kiel, Germany.ORCID 0000-0001-7208-4117
S GramlichJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.
J DollJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.
S RothJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.
K MaurusJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.
A M StaigerRobert Bosch Krankenhaus, Department of Clinical Pathology, Stuttgart, Germany.
R SiebertUlm University and Ulm University Medical Center, Institute of Human Genetics, Ulm, Germany.ORCID 0000-0001-7433-3703
M-Q DuUniversity of Cambridge, Department of Pathology, Cambridge, UK.ORCID 0000-0002-1017-5045
A RosenwaldJulius-Maximilians-Universität Würzburg, Institute of Pathology, Würzburg, Germany.
G OttRobert Bosch Krankenhaus, Department of Clinical Pathology, Stuttgart, Germany. German.Ott@rbk.de.ORCID 0000-0001-7990-6793
H HornRobert Bosch Krankenhaus, Department of Clinical Pathology, Stuttgart, Germany.ORCID 0000-0002-2933-005X

Funding

Robert Bosch Stiftung (Robert Bosch Foundation) Project O3
6 · The paper itself

Abstract

Rearrangement of Cyclin D1 (CCND1-R) is the hallmark genetic lesion of mantle cell lymphoma (MCL). However, recently diffuse large B-cell lymphomas (DLBCL) have been described carrying a CCND1-R, often with additional rearrangements of BCL2, BCL6 and/or MYC raising the question if these are bona fide DLBCL or pleomorphic MCL. Protein expression and fluorescence in situ hybridisation (FISH) screening of 708 aggressive B-cell lymphomas failed to disclose CCND1-R, demonstrating the rarity of such cases. Fifteen large B-cell tumours, with CCND1-R were collected from different institutions and characterized by immunohistochemistry and for their molecular features. Three of 15 cases were CD5 positive, and all cases were negative for SOX11 but exhibited cyclin D1 staining and CCND1-R by FISH. In 10/15 cases IG could be determined as rearrangement partner by FISH or WGS with occurrence of both aberrant VDJ rearrangement and IGH class-switch recombination (CSR). Eight of 15 tumours had additional translocations involving MYC, BCL2, or BCL6. 8/12 evaluable cases showed significantly mutated IGHV genes and evidence of intraclonal variations in their rearranged IGHV genes. WES disclosed a mutational spectrum typical of DLBCL in 14/14 evaluable cases. We conclude that DLBCL CCND1-R do exist and that CCND1-R in DLBCL can occur without additional translocations.

Indexed as

Cyclin D1Gene RearrangementLymphoma, Large B-Cell, DiffuseAdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansIn Situ Hybridization, FluorescenceLymphoma, Mantle-CellMaleMiddle AgedTranslocation, GeneticBiomarkers, TumorCCND1 protein, humanCyclin D1

Identifiers

PMID41204003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.