ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Factors associated with persistent bloodstream infection in the Neonatal Intensive Care Unit.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study determined factors associated with persistent bloodstream infections (BSIs) for infants in the NICU to identify when follow up blood cultures (FUBCs) have increased utility. STUDY
designSingle center study of all infants in a level IV NICU (n = 121) with a positive blood culture over a five-year period. Clinical and microbiological variables were examined with bivariate and multi-regression analyses to identify factors associated with persistent BSI, defined as growth of the same organism >48 h after the index culture.
resultsThe recovery of Staphylococcus aureus (OR = 6.10, p < 0.001), male sex (OR = 3.31, p = 0.020), the presence of a central venous catheter (OR = 3.73, p = 0.020), and BSI in the setting of late-onset sepsis (p < 0.001) were associated with persistent BSI. No infants with either early-onset sepsis or growth of Streptococcal sp. had a persistent BSI.
conclusionIn the NICU, both patient and microbial characteristics can inform diagnostic stewardship regarding the need for FUBCs.
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