Evidence map›Paper›PMID 41203891›Full record

ArticleNPJ digital medicine2025

A generalizable 3D framework and model for self-supervised learning in medical imaging.

Tony Xu, Sepehr Hosseini, Chris Anderson, Anthony Rinaldi, Rahul G Krishnan, Anne L Martel, Maged Goubran

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multi-Scale Feature Fusion with Image-Driven Spatial Integration for Left Atrium Segmentation from Cardiac MR Images.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tony XuDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Sepehr HosseiniDepartment of Computer Science, University of Toronto, Toronto, ON, Canada.
Chris AndersonInstitute for Aerospace Studies, University of Toronto, Toronto, ON, Canada.
Anthony RinaldiPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.
Rahul G KrishnanDepartment of Computer Science, University of Toronto, Toronto, ON, Canada.
Anne L MartelDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Maged GoubranDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada. maged.goubran@utoronto.ca.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
Canada Research Chairs program CRC-2021-00374Canadian Foundation for Innovation 43890Google Research PhD fellowshipNatural Sciences and Engineering Research Council (NSERC) RGPIN-2021-03728Natural Sciences and Engineering Research Council of Canada PGS-DNCATS NIH HHS UL1 TR000448NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG043434NIA NIH HHS U19 AG024904NIBIB NIH HHS R01 EB009352NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Current self-supervised learning (SSL) methods for 3D medical imaging rely on simple pretext formulations and organ- or modality-specific datasets, limiting their generalizability and scalability. We present 3DINO, a cutting-edge SSL method adapted to 3D datasets, and pretrain 3DINO-ViT: a general-purpose model for medical imaging, on a ultra-large multimodal dataset of ~100,000 3D scans from over 10 organs. We show 3DINO-ViT outperforms state-of-the-art pretrained models on numerous downstream imaging tasks.

Identifiers

PMID41203891
PMCPMC12594808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.