Evidence map›Paper›PMID 41203885›Full record

ArticleHerz2026

Procedural hospital volume and outcome after transcatheter edge-to-edge mitral valve repair : Analysis of the German mandatory quality registry.

Julinda Mehilli, Maike Bestehorn, Christian Perings, Volker Schächinger, Hendrik Schmidt, Ralf Zahn, Christoph Stellbrink, Ilka Ott, Raffi Bekeredjian, Florian Zauner and 1 more

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Article in Herz, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julinda MehilliMedizinische Klinik I, Lakumed Hospital Landshut-Achdorf, Landshut, Germany. Julinda.mehilli@lakumed.de.ORCID http://orcid.org/0009-0001-1078-6807
Maike BestehornProMedCon GmbH, Ebenhausen, Germany.
Christian PeringsMedizinische Klinik I, St.-Marien-Hospital, Lünen, Germany.
Volker SchächingerMedizinische Klinik I, Herz-Thorax Zentrum, Klinikum Fulda, Fulda, Germany.
Hendrik SchmidtKlinik für Kardiologie und Diabetologie, Klinikum Magdeburg, Magdeburg, Germany.
Ralf ZahnMedizinische Klinik B, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen am Rhein, Germany.
Christoph StellbrinkUniversitätsklinik für Kardiologie und Internistische Intensivmedizin, Klinikum Bielefeld, Bielefeld, Germany.
Ilka OttKlinik für Kardiologie, Helios Klinikum, Pforzheim, Germany.
Raffi BekeredjianKlinik für Kardiologie und Angiologie, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
Florian ZaunerMedizinische Klinik I, Lakumed Hospital Landshut-Achdorf, Landshut, Germany.
Kurt BestehornTechnical University Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies assessing transcatheter edge-to-edge mitral valve repair (M-TEER) suggest lower rates of in-hospital mortality (IHM) at high-volume hospitals, and guidelines recommend minimum caseloads to assure quality standards.

methodsData from all patients undergoing M‑TEER procedures at 154 hospitals in the German mandatory quality assurance registry in 2020 were analyzed. The observed IHM was adjusted against the expected mortality predicted by the German MKL-KATH score (O/E) and EuroScore II (O/E2). Regression analyses and volume quartile analyses were performed on hospital volume (HV), IHM rate, O/E, and intra-hospital complications. Additionally, binomial analysis was performed to verify results.

resultsA total of 5099 patients (age 77.9 ± 2.5 years, mean EuroScore II 17.9 ± 5.9%) underwent M‑TEER procedures during the study period. The mean observed IHM was 1.79 ± 3.4%. Neither unadjusted nor risk-adjusted IHM was related to HV in linear regression (adjusted p = 0.56) or logistic regression (p = 0.515) analyses. The IHM rates for the first and fourth quartiles were nearly identical (p = 0.842). Any selected volume cut-off could not differentiate between hospitals with unacceptable (> 95th percentile O/E of all hospitals), acceptable (O/E ≤ 95th percentile), or better-than-average quality (O/E < 1). A caseload cut-off of 30cases per year would exclude 83 hospitals with acceptable or 72 with better-than-risk-adjusted quality (54% and 47% of all hospitals, respectively).

conclusionHospital volume is an imprecise surrogate for assessing the quality of hospitals performing M‑TEER. The association between HV and IHM in patients undergoing elective M‑TEER in Germany was weak and not consistent across various analytical approaches. Other instruments may be more suitable for identifying hospitals with critical performance levels.

Indexed as

Hospitals, High-VolumeMitral Valve InsufficiencyPostoperative ComplicationsRegistriesTranscatheter Mitral Valve ReplacementAgedFemaleGermanyHospital MortalityHumansMaleQuality Assurance, Health CareRisk FactorsTreatment OutcomeCaseloadHeart failureMitral valve regurgitationPeriprocedural complicationsValve repair

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.