Evidence map›Paper›PMID 41203851›Full record

Trial reportScientific reports2025

Aortic calcification is associated with decreased abdominal aortic aneurysm growth.

Sydney L Olson, Valentyna Kostiuk, Tanner I Kim, John A Curci, Timothy Baxter, Jon S Matsumura, William C Blackwelder, Michael L Terrin, Raul J Guzman

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sydney L OlsonDepartment of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, USA.
Valentyna KostiukDivision of Vascular Surgery and Endovascular Therapy, Yale School of Medicine, New Haven, USA.
Tanner I KimDepartment of Vascular surgery, Queen's Health System, Honolulu, HI, USA.
John A CurciDepartment of Vascular Surgery, Vanderbilt University Medical Center, Nashville, USA.
Timothy BaxterDivision of Vascular Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, USA.
Jon S MatsumuraDivision of Vascular Surgery, Department of Surgery, University of Colorado, Aurora, USA.
William C BlackwelderDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Michael L TerrinDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Raul J GuzmanDivision of Vascular Surgery and Endovascular Therapy, Yale School of Medicine, New Haven, USA. Raul.guzman@yale.edu.

Funding

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT )R01AG037120 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI BAXTER, BERNARD TIMOTHY, CURCI, JOHN A · 2011 to 2017
$12.2M
RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
Doxycycline Treatment of Abdominal Aortic Aneurysm: PlanningR34AG028684 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L. · 2007 to 2007
$101k
NIA NIH HHS R01 AG037120NIA NIH HHS R01 HL 138357 R34 AG028684, R01 AG037120, T32 AG000262, and P30 AG0288747NIA NIH HHS R34 AG028684NIA NIH HHS T32 AG000262
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) rupture remains a significant cause of morbidity and mortality, but predictors of continued growth and rupture risk remain limited. The aim of this study was to investigate the relationship between abdominal aortic calcification and AAA growth via a secondary cohort analysis of the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT), a prospective multicenter randomized study. Arterial calcification Agatston scores and maximum transverse diameter were measured in non-contrast computed tomography (CT) scans in patients enrolled in N-TA3CT. Uni- and multi-variable linear regression were used to assess the association of anatomic calcium burden and comorbid conditions with rate of aneurysm growth. Of the 261 randomized patients in the trial, 136 patients met inclusion criteria for analysis. On univariable analysis, baseline calcium score at all assessed anatomic locations- the superior mesenteric artery (spearman correlation coefficient (SCC) -0.20, p = 0.0176), renal artery (-0.22, p = 0.0120, infrarenal aorta (-0.26, p = 0.0020), common iliac artery (-0.19, p = 0.024), external iliac artery (-0.26, p = 0.003), and sum of all measured sites (-0.28, p = 0.001)- was significantly associated with lower AAA diameter growth rates. Of individually measured sites, baseline infrarenal aortic calcification had the strongest negative association with aneurysm growth. Interestingly, infrarenal calcium score was not significantly associated with baseline aneurysm diameter (R

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalVascular CalcificationAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsTomography, X-Ray ComputedAAAAbdominal aortic aneurysmAgatston scoreAneurysm growthArterial calcificationCalcium score

Identifiers

PMID41203851
PMCPMC12594760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.