ArticleJournal of exposure science & environmental epidemiology2026
Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort.
Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.Journal of the Endocrine Society · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundOrganophosphate esters and plasticizers (OPEs) are used in consumer materials to meet flammability standards. Toxicological and epidemiological evidence suggests some OPEs are developmental neurotoxicants.
objectiveWe investigated associations between OPE exposures as measured in house dust and emotional and behavioral problems in young children.
methodsWe used data from the CHILD Cohort Study (n = 601), a prospective birth cohort recruited in 5 cities across Canada (2008-2012). OPEs were measured in house dust at 3-4 months postpartum, and parents completed the Child Behavior Checklist (CBCL), which measures emotional and behavioral problems when their child was 5 years. We used logistic regression to examine associations between OPE Z-scores (individual and summed chlorinated [ΣOPE
resultsTris(2-chloroethyl) phosphate (TCEP) showed strong, positive associations with CBCL Total and Externalizing scores at or above the clinical cutoff, meaning children with higher levels of TCEP in house dust postpartum had higher odds of developing clinically relevant behavioral problems in early childhood compared to children with lower levels (Total OR IMPACT: Organophosphate esters (OPEs) are common aspects of our built environment and increasingly recognized as developmental neurotoxicants. Using data from a large Canadian birth cohort, we investigated associations between OPE exposures as measured in house dust postpartum and emotional and behavioral problems in children. We found that levels of two OPE compounds (tris(2-chloroethyl) phosphate and a component of Firemaster 550) were associated with increased odds of clinically relevant behavioral problems in early childhood. This important work underscores the urgent need for public health policies to limit the use of certain OPEs in consumer products to reduce children's exposure to harmful chemicals.
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