ArticleScientific reports2025
Streamlined spectrofluorimetric assay for Pramipexole using acid red 87 quenching strategy for tablet and uniformity evaluation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Spectrofluorimetric quantification of terconazole in pharmaceutical creams with comprehensive sustainability evaluation.BMC chemistry · 2026Article
- Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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Abstract
Pramipexole (PPX) is prescribed for alleviating parkinson's disease symptoms like tremors and mobility issues, as well as addressing the discomfort in the legs and sudden leg movement impulses associated with restless legs syndrome. This study presents a practical, direct, non-extractive, and cost-effective analytical strategy for the quantitative determination of PPX. The method leverages fluorimetric detection, specifically monitoring the quenching effect on the emission intensity of Acid red 87, a fluorone dye. Complexation between PPX and Acid Red 87 occurs rapidly within a single reaction vessel under acidic conditions. A linear relationship was established between the observed decrease in Acid red 87 fluorescence intensity and PPX concentration, enabling the construction of a calibration curve spanning 50 to 1400 ng/mL. Critical variables influencing the PPX-dye complex system were systematically investigated and optimized. Comprehensive validation studies, conducted in accordance with International Council for Harmonisation (ICH) guidelines, confirmed the method's reliability. The validated approach was subsequently applied successfully to assay PPX in pharmaceutical tablets and to evaluate tablet content uniformity.
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