Evidence map›Paper›PMID 41203737›Full record

ArticleScientific reports2025

BioAgents: Bridging the gap in bioinformatics analysis with multi-agent systems.

Nikita Mehandru, Amanda K Hall, Olesya Melnichenko, Yulia Dubinina, Daniel Tsirulnikov, David Bamman, Ahmed Alaa, Scott Saponas, Venkat S Malladi

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nikita MehandruUniversity of California, Berkeley, Berkeley, CA, USA.
Amanda K HallHealth Futures, Microsoft Research, Redmond, WA, USA.
Olesya MelnichenkoHealth Futures, Microsoft Research, Redmond, WA, USA.
Yulia DubininaHealth Futures, Microsoft Research, Redmond, WA, USA.
Daniel TsirulnikovHealth Futures, Microsoft Research, Redmond, WA, USA.
David BammanSchool of Information, University of California, Berkeley, Berkeley, CA, USA.
Ahmed AlaaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Scott SaponasHealth Futures, Microsoft Research, Redmond, WA, USA.
Venkat S MalladiHealth Futures, Microsoft Research, Redmond, WA, USA. vsmalladi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing end-to-end bioinformatics workflows is challenging, demanding deep expertise in both genomics and computational techniques. While large language models (LLMs) provide some assistance, they often lack the nuanced guidance required for complex bioinformatics tasks, and are resource-intensive. We thus propose a multi-agent system built on small language models, fine-tuned on bioinformatics data, and enhanced with retrieval augmented generation (RAG). Our system, BioAgents, enables local operation and personalization using proprietary data. We observe performance comparable to human experts on conceptual genomics tasks, and discuss future work to enhance code generation capabilities.

Indexed as

Computational BiologyGenomicsHumansSoftwareWorkflow

Identifiers

PMID41203737
PMCPMC12594986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.