Evidence map›Paper›PMID 41203721›Full record

ArticleScientific reports2025

Suitability of prolonged meloxicam treatment in mice seems limited due to unfavorable pharmacokinetics, side effects, and impact on home-cage behaviors.

Aylina Glasenapp, Jens P Bankstahl, Heike Bähre, Jana Hauser, Amisha R Parmar, Andrey V Kozlov, Silke Glage, Rupert Palme, Marion Bankstahl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aylina GlasenappInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.
Jens P BankstahlDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Heike BähreResearch Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
Jana HauserDepartment of Biological Sciences and Pathobiology, Center for Biological Sciences, Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.
Amisha R ParmarDepartment of Biological Sciences and Pathobiology, Center for Biological Sciences, Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.
Andrey V KozlovLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
Silke GlageInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.
Rupert PalmeDepartment of Biological Sciences and Pathobiology, Center for Biological Sciences, Experimental Endocrinology, University of Veterinary Medicine Vienna, Vienna, Austria.
Marion BankstahlInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany. bankstahl.marion@mh-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meloxicam is commonly used for analgesia, but no preparation approved specifically for use in mice. Here, we determined plasma concentrations, safety, and impact on home-cage behaviors for subcutaneous injection (5 mg/kg) and oral self-intake (sweetened drinking water, 20 mg/kg/24h, 5 days) for C57BL/6J mice (n = 21/sex). After injection, plasma concentrations measured by LC-MS/MS were higher in females (2h) and remained within an estimated therapeutic range (390-911 ng/mL) for up to 6h. T

Indexed as

Anti-Inflammatory Agents, Non-SteroidalBehavior, AnimalMeloxicamAdministration, OralAnimalsFemaleInjections, SubcutaneousMaleMiceMice, Inbred C57BLAnti-Inflammatory Agents, Non-SteroidalMeloxicam

Identifiers

PMID41203721
PMCPMC12594854

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.