Evidence map›Paper›PMID 41203691›Full record

ArticleScientific reports2025

Mucoadhesive lyophilized wafers loaded with nano-spanlastic felodipine formulation: development and characterization.

Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Malakapogu Ravindra Babu, Padmanabha Rao Amarachinta, Narender Boggula, Achor Mohammed

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ananda Kumar ChettupalliSchool of Pharmaceutical Technology, Department of Pharmaceutical Technology, Medical studies, Adamas University, Barbaria, West Bengal, 700126, India. ananda.chettupalli@galgotiasuniversity.edu.in.ORCID http://orcid.org/0000-0003-4359-7145
Sarad Pawar Naik BukkeDepartment of Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, P.O. Box 71, Ishaka, Bushenyi, Uganda. drsaradpawar@kiu.ac.ug.ORCID http://orcid.org/0000-0002-5693-2953
Malakapogu Ravindra BabuDepartment of Pharmaceutical Sciences, Anurag University, Hyderabad, Telangana, 500088, India.
Padmanabha Rao AmarachintaDepartment of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Medchal, Telangana, 501 301, India.
Narender BoggulaDepartment of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Medchal, Telangana, 501 301, India.
Achor MohammedDepartment of Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, P.O. Box 71, Ishaka, Bushenyi, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Felodipine (FDP) is used to treat hypertension and angina pectoris. FDP has an oral bioavailability of approximately 15% in humans, primarily due to its poor water solubility and extensive first-pass metabolism in the liver and gut wall. The study aimed to develop and evaluate a lyophilized buccal wafer containing felodipine-loaded nano-spanlastics to enhance solubility, permeability, and therapeutic efficacy. FDP-loaded nano-Spanlastics (FDP-SL) using a 2

Indexed as

Drug CompoundingFelodipineHypertensionNanoparticle Drug Delivery SystemAdministration, BuccalAnimalsAntihypertensive AgentsCadmium ChlorideCattleDisease Models, AnimalDrug LiberationMouth MucosaParticle SizePolysorbatesRatsRats, WistarAntihypertensive AgentsCadmium ChlorideFelodipineNanoparticle Drug Delivery SystemPolysorbatesBuccal deliveryCarboxy methyl celluloseFelodipineNano SLPlendilTween 80

Identifiers

PMID41203691
PMCPMC12594815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.