Evidence map›Paper›PMID 41203661›Full record

ArticleScientific reports2025

Methyl jasmonate elicitation enhances photoprotective and anti-inflammatory properties in Lavandula angustifolia cell suspension cultures.

Dong-Ho Bak, Bo Ryeong Kim, Ki-Hyun Kim, Gyeongchan Jeon, Yu Jeong Jeong, Soyoung Kim, Ok Ran Lee, Jae Cheol Jeong, Cha Young Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dong-Ho BakBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Bo Ryeong KimBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Ki-Hyun KimBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Gyeongchan JeonBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Yu Jeong JeongBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Soyoung KimBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea.
Ok Ran LeeDepartment of Applied Plant Science, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
Jae Cheol JeongBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea. jcjeong@kribb.re.kr.
Cha Young KimBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 181 Ipsin-gil, Jeongeup-si, Jeonbuk, 56212, Republic of Korea. kimcy@kribb.re.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress and inflammation induced by ultraviolet (UV) exposure significantly accelerate skin aging, necessitating effective bioactive agents to prevent photodamage. This study investigates the antioxidant and anti-inflammatory properties of cell extracts from Lavandula angustifolia cell suspension cultures, assessing their potential applications in preventing skin aging and mitigating inflammation. L. angustifolia cell suspension cultures were established from callus derived from lavender stem tissues. Notably, treatment with methyl jasmonate (MJ) significantly enhanced secondary metabolite production, as confirmed by gas chromatography-mass spectrometry analysis. The MJ-treated lavender cell extract (LC-MJ) improved cell viability and inhibited early apoptosis in mouse fibroblasts exposed to ultraviolet B-induced oxidative stress. Additionally, LC-MJ extract effectively downregulated inflammatory pathways in lipopolysaccharide-induced RAW 264.7 macrophages by reducing the secretion of pro-inflammatory cytokines, including TNF-α and IL-6. This anti-inflammatory effect was associated with the inhibition of MAPK and NF-κB signaling pathways, indicating a protective role in inflammation-related conditions. These observations imply that LC-MJ extract could be utilized as a functional bioactive agent in the management of oxidative stress and inflammation, particularly in the prevention of skin aging and UV-induced photodamage.

Indexed as

AcetatesAnti-Inflammatory AgentsCyclopentanesLavandulaOxylipinsAnimalsAntioxidantsApoptosisCell SurvivalFibroblastsInflammationMiceOxidative StressPlant ExtractsRAW 264.7 CellsUltraviolet RaysAcetatesAnti-Inflammatory AgentsAntioxidantsCyclopentanesmethyl jasmonateOxylipinsPlant ExtractsAnti-inflammatoryAntioxidantCell extractCell suspension culturesLavandula angustifoliaMethyl jasmonate

Identifiers

PMID41203661
PMCPMC12595083

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.