ArticleNature communications2025
Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Spatial Evolution of Antimicrobial Metallopolymers toward the Main Chain Topology.ACS central science · 2026Article
- Exploring halophilic microorganisms for novel antimicrobial discovery: molecular mechanisms and computational approaches.Folia microbiologica · 2026Review
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Authors and funding
10 authors.
Funding
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Abstract
Drug resistance in bacteria is a major problem that calls for new classes of antimicrobial drugs. We report a biodegradable poly(imidazolium ester) (PIE), P8, with excellent broad-spectrum antibacterial activity, high therapeutic selectivity, and an unexploited mechanism of action. P8, a short oligomer, translocates across bacterial membrane and phase separates with intracellular nucleic acids, forming biomolecular condensates. P8 binds the DNA minor groove and intercalates with DNA, interacting with it via electrostatic and hydrogen-bonding interactions. The phase separation of nucleic acids modulated by P8 inhibits in vitro transcription, thereby impeding translation and potentially leading to cell death. Bacterial cytological profiling indicates that the antimicrobial mechanism of P8 differs from those of conventional antibiotics, though it also suggests that P8 may inhibit RNA synthesis. P8 is safe and effective against drug-resistant bacteria in murine models of systemic, intramuscular, and lung infections. This study shows the great potential of intracellular biomolecular condensate formation for combating drug-resistant bacteria.
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