ArticleNature communications2025
Clinical ultrasound, photoacoustic, and fluorescence image-guided lymphovenous anastomosis microsurgery via a transparent ultrasound transducer array.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- Volumetric photoacoustic imaging of elastin and age-related remodeling using near-infrared probe ElaNIR.Photoacoustics · 2026Article
- Electrically switchable dual-focus metalens for depth-extended in vivo photoacoustic imaging of ophthalmic vascular disease.Light, science & applications · 2026Article
- A Low-Cost, Lightweight High-Frequency Ultrasound Transducer with Aluminum Electrodes and 3D-Printed Polymer Housing.Biosensors · 2026Article
- Maximum fluence for accurate functional photoacoustic microscopy.Photoacoustics · 2026Article
- Noninvasive whole-brain imaging of glymphatic dynamics.Science advances · 2026Article
- [Research progress of photoacoustic imaging in diagnosis of limb lymphedema].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Fabrication of optically transparent ultrasound transducers to integrate light and sound in multimodal biomedical systems.Nature protocols · 2026Review
- Fully integrated photoacoustic microscopy for multi-scale and longitudinal imaging in translational biomedical applications.Biomedical optics express · 2026Article
- Volumetric photoacoustic/ultrasound image fusion and enhancement with dual-tree complex wavelet transform.Biomedical optics express · 2026Article
- Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication.Molecular biomedicine · 2026Review
- Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026Review
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Ultrasound-induced luminescence imaging for deep tissues.Theranostics · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Multimodal optical and ultrasound imaging (USI) provides complementary diagnostic insights. However, because conventional USI uses opaque ultrasound (US) transducers, integrating these two modalities results in a bulky and complicated handheld probe in which neither modality performs efficiently. Although transparent ultrasound transducers (TUTs) solve these issues by acting as optical windows, enabling the seamless combination of light and US beams, single-element TUTs are not common in clinical environments. Here, we demonstrate a clinical triple-modal US, photoacoustic, and fluorescence imaging system, seamlessly integrated via a linear TUT-array. This system, with 64 channels and a 7-MHz center frequency achieves 72.7% optical transparency in the near infrared region. The system's handheld opto-US probe coaxially integrates the TUT-array with a miniaturized camera and an optical fiber in a small form factor. The triple-modal imaging system effectively visualizes tissue structures, vasculatures, and lymphatics in real time in live animals, healthy volunteers, and lymphedema patients. By accurately mapping superficial tissues, blood vessels, and lymphatic vessels, we use the prototype system to successfully guide lymphovenous anastomosis microsurgery. These preclinical demonstrations illustrate the potential use of our system in various clinical procedures requiring microsurgical guidance, paving the way for future advances in multimodal imaging.
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Registered trials
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