Evidence map›Paper›PMID 41203626›Full record

ArticleOncogenesis2025

NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression.

Suyang Zhang, Guangyao Xu, Tianyu Cao, Fei Yu, Moses Okotel, Mingyue Wu, Shourong Wu, Vivi Kasim, Can Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suyang Zhang *Metabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Guangyao Xu *Metabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Tianyu Cao *Metabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Fei YuMetabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Moses OkotelMetabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Mingyue WuStomatologic Hospital&College, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China.
Shourong WuKey Laboratory of Biological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China. shourongwu@cqu.edu.cn.ORCID http://orcid.org/0000-0001-9650-5465
Vivi KasimKey Laboratory of Biological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China. vivikasim@cqu.edu.cn.ORCID http://orcid.org/0000-0001-9182-8230
Can HuangMetabolic Disease Research Center, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China. huangcan@ahmu.edu.cn.ORCID http://orcid.org/0000-0001-8373-2829

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82203424Natural Science Foundation of Anhui Province (Anhui Provincial Natural Science Foundation) 2108085QH338
6 · The paper itself

Abstract

The pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of activated T-cells c1 (NFATc1) promotes oncogenesis in various cancers, its role in metabolic reprogramming remains unclear. Here, we demonstrate that NFATc1 enhances NAD kinase (NADK) expression, elevating intracellular NADP

Identifiers

PMID41203626
PMCPMC12594948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.