ArticleNature communications2025
Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development of advanced bioinformatic profiles to improve the detection and functional understanding of fungal acid phosphatases.Applied and environmental microbiology · 2026Article
- Stage-Dependent Dynamics and Assembly Processes ofMicroorganisms · 2026Article
- Polysaccharide Utilization and Adhesion Enable the Genome-StreamlinedMicroorganisms · 2026Article
- Major contribution of anaplerosis to inorganic carbon fixation in the dark ocean.Nature geoscience · 2026Article
- Marine bacteria degrade viral particles as a source of nitrogen, phosphorus, and sulfur-rich dissolved organic matter.ISME communications · 2026Article
- The marine phosphorus cycle driven by an unlikely microbe.Nature communications · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus is a critically limiting nutrient in marine ecosystems, with alkaline phosphatases (APases) playing a vital role in liberating phosphate from organic compounds. However, the dominant taxa and APase families driving the marine phosphorus cycle, particularly in the deep ocean, remain poorly understood. Equally enigmatic remains the (multi)functional diversity and mechanisms of action of different APases. To address these gaps, this study combines global multi-omic analyses, biochemical studies of purified recombinant proteins, and laboratory experiments with proteomics and enzymatic rate measurements. Here we show that multi-omics consistently identify Alteromonas as a primary contributor to APase expression and production, with PhoA as the dominant APase family, particularly in the deep ocean. Furthermore, all four major APase families (PhoA, PhoD, PhoX, PafA) exhibit multifunctionality, revealing distinct substrate preferences and regulatory mechanisms. Ultimately, this study expands the mechanistic understanding of the marine phosphorus cycle, while revealing the significance of enzyme multifunctionality in elemental cycles.
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