ArticleNature communications2025
Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria.NPJ biofilms and microbiomes · 2026Trial
- Hunting for Helminths: short- and long-read shotgun metagenomics for helminth detection in faecal samples.PLoS neglected tropical diseases · 2026Article
- Molecular characterization of the prevalent soil-transmitted helminths in Narathiwat Province, southern Thailand.PloS one · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Soil-transmitted helminthiases, particularly trichuriasis, affect over 500 million people, mostly in low- and middle-income countries. Traditional diagnostics fail to distinguish between Trichuris species, obscuring transmission patterns and treatment outcomes. Using nanopore-based full-length ITS2 rDNA sequencing, we analyzed 687 samples from Côte d'Ivoire, Laos, Tanzania, and Uganda, confirming the phylogenetic placement of two genetically distinct Trichuris species infecting humans, Trichuris trichiura and the recently described Trichuris incognita. The two Trichuris species reveal divergent geographic patterns and also presence in non-human primates, suggesting complex host-parasite dynamics. Within-country genetic variation indicates local adaptation and cryptic population structure. Importantly, we demonstrate that ITS2 fragment length is a robust, cost-effective diagnostic marker for differentiating T. incognita and T. trichiura, offering a practical alternative to sequencing for resource-limited settings. These findings expose the hidden complexity of Trichuris spp. infections and highlight the urgent need to update diagnostic and control strategies to account for overlooked species diversity in endemic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.