Evidence map›Paper›PMID 41203612›Full record

ArticleNature communications2025

Age modulates the link between stress-related neural activity and mortality.

Nidaa Mikail, Noemi Sablonier, Pimrapat Gebert, Isabelle Glarner, Adriana Vinzens, Achi Haider, Atanas Todorov, Susan Bengs, Angela Portmann, Valerie Treyer and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nidaa Mikail *Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4896-1428
Noemi Sablonier *Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Pimrapat GebertDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5946-7137
Isabelle GlarnerDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0007-5000-9707
Adriana VinzensDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0000-5491-3233
Achi HaiderDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Atanas TodorovDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1225-4302
Susan BengsDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Angela PortmannDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0973-5439
Valerie TreyerDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Susanne WegenerDepartment of Neurology and Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4369-7023
Christoph GräniDepartment of Cardiology, Bern University Hospital Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-6029-0597
Aju P PazhenkottilDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Caroline E GebhardIntensive Care Unit, Department of Acute Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Vera Regitz-ZagrosekInstitute of Gender in Medicine (GiM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Felix C TannerDepartment of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9451-5210
Ronny R BuechelDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8064-8904
Alexia RossiDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Catherine GebhardDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland. catherine.gebhard@insel.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress-related neural activity (SNA), as measured by amygdala metabolism, has been linked in prior work to all-cause mortality and major adverse cardiovascular events. In this study, we sought to clarify SNA determinants and test whether age modifies its association with all-cause mortality. Using 2-[18 F]fluoro-2-deoxy-D-glucose positron emission tomography (

Indexed as

AmygdalaMortalityStress, PsychologicalAdultAgedAge FactorsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyFluorodeoxyglucose F18

Identifiers

PMID41203612
PMCPMC12594861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.