Evidence map›Paper›PMID 41203610›Full record

ArticleNature communications2025

Microglia alter sex-specific cerebellar myelination following placental hormone loss.

Jacquelyn Salzbank, Helene Lacaille, Jenah Gaby, Jiaqi J O'Reilly, Michael Kissner, Claire-Marie Vacher, Anna A Penn

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacquelyn SalzbankDepartment of Pediatrics, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Helene LacailleDepartment of Pediatrics, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Jenah GabyDepartment of Pediatrics, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Jiaqi J O'ReillyNational Institutes of Health, Bethesda, MD, USA.
Michael KissnerColumbia Stem Cell Initiative, Columbia University Medical Center, New York, NY, USA.
Claire-Marie Vacher *Department of Pediatrics, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Anna A Penn *Department of Pediatrics, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. aap2216@columbia.edu.ORCID http://orcid.org/0000-0003-1539-5220

Funding

Novel Roles of Placental Allopregnanolone in Brain Development and InjuryR01HD092593 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANNA A PENN · 2017 to 2026
$3.9M
ADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0M
Fetal Brain Damage: A Placental DisorderDP2OD006457 · OD · STANFORD UNIVERSITY · PI PENN, ANNA A · 2009 to 2009
$2.4M
Millipore Sigma ImageStream-X Mark II Imaging CytometerS10OD026845 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PASSEGUE, EMMANUELLE · 2019 to 2019
$553k
Therapeutic agents to prevent developmental neuroimpairment after placental hormone lossR21HD109623 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PENN, ANNA A · 2022 to 2023
$452k
NICHD NIH HHS R01 HD092593NICHD NIH HHS R21 HD109623NIH HHS DP2 OD006457NIH HHS S10 OD026845NINDS NIH HHS T32 NS064928Simons Foundation 572832U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD092593U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R21HD109623U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) T32NS064928U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) S10OD026845
6 · The paper itself

Abstract

Placental dysfunction is linked to neurodevelopmental disorders, with males showing greater vulnerability to perinatal inflammation-mediated brain injuries. Using our transgenic mouse model, Akr1c14

Indexed as

CerebellumMicrogliaMyelin SheathPlacentaPregnanoloneAnimalsAromataseDinoprostoneFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhagocytosisPregnancyAromataseDinoprostonePregnanolone

Identifiers

PMID41203610
PMCPMC12594813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.