Evidence map›Paper›PMID 41203433›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Gene Expression-Based Lesion-Symptom Mapping:

Janina Wilmskoetter, Sigfus Kristinsson, Ida Rangus, Natalie Busby, Chris Rorden, Dirk den Ouden, Roger Newman-Norlund, Carolyn Banister, Nicholas Riccardi, Alex Teghipco and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janina WilmskoetterDepartment of Rehabilitation Sciences, College of Health Professions, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID 0000-0002-1083-7301
Sigfus KristinssonDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.ORCID 0000-0002-0459-5369
Ida RangusDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Natalie BusbyDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Chris RordenPsychology, University of South Carolina, Columbia, South Carolina 29208.
Dirk den OudenDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Roger Newman-NorlundDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Carolyn BanisterDrug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208.
Nicholas RiccardiPsychology, University of South Carolina, Columbia, South Carolina 29208.ORCID 0000-0001-7243-6100
Alex TeghipcoDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Sarah Newman-NorlundDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Julius FridrikssonDepartments of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208.
Leonardo BonilhaDepartment of Neurology, University of South Carolina, Columbia, South Carolina 29209 bonilha@sc.edu.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2016 to 2025
$25.0M
Cortical and Subcortical Organization of Language-Related Semantic Processing in Alzheimer's DiseaseR01DC014021 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2014 to 2023
$4.7M
Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II TrialU01DC011739 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2012 to 2016
$4.4M
Speech Entrainment for Aphasia Recovery (SpARc)U01DC017521 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BONILHA, LEONARDO F, FRIDRIKSSON, JULIUS · 2019 to 2023
$4.2M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC014021NIDCD NIH HHS U01 DC011739NIDCD NIH HHS U01 DC017521
6 · The paper itself

Abstract

Chronic language impairments, aphasia, are a common consequence of stroke, yet the factors influencing their severity remain poorly understood. Although lesion location is widely recognized as a key determinant of aphasia severity and recovery, the impact of gene expression within the affected brain regions is largely unexplored. In this proof-of-concept study, we introduce a novel computational approach termed gene expression-based lesion-symptom mapping (GLSM). We sought to investigate whether mapping stroke lesions to brain regions with heightened expression of certain genes could offer insights into aphasia severity. For demonstration purposes, we chose the gene

Indexed as

AphasiaBrainBrain MappingForkhead Transcription FactorsStrokeAdultAgedFemaleGene ExpressionHumansMagnetic Resonance ImagingMaleMiddle AgedForkhead Transcription FactorsFOXP2 protein, humanaphasiaFOXP2gene expressionstroke

Identifiers

PMID41203433
PMCPMC12828873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.