ArticleJACC. Case reports2025
ABCC6-Related Left Ventricular Papillary Muscle Calcification.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Papillary Muscle Calcification as a Rare Cardiac Manifestation of β-Thalassemia-Related Pseudoxanthoma Elasticum-Like Syndrome.Balkan medical journal · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtensive papillary muscle calcification may be observed in ischemic heart disease or after thoracic radiotherapy. Rarely, it can be part of an underlying Mendelian disorder. CASE SUMMARY: A 70-year-old woman presented with bilateral angioid streaks on funduscopy, identified after a transient ischemic attack. Echocardiography when she was 49 years old had revealed extensive papillary muscle calcification, partially involving the left ventricular apex. A diagnosis of pseudoxanthoma elasticum (PXE) was suspected based on genetic analysis (multiexon deletion in ABCC6), skin biopsy, and plasma pyrophosphate measurement. DISCUSSION: This is to our knowledge the first case of papillary muscle calcification due to ABCC6-related PXE. TAKE-HOME MESSAGE: Extensive or peculiar cardiovascular calcification observed in a patient-including extensive papillary muscle calcification-should prompt further diagnostic evaluation of other organ systems, followed by a low threshold for genetic testing if an underlying hereditary calcification disorder such as PXE is suspected.
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