ArticleEuropean journal of dentistry2026
Effect of Centrifugation Methods on the Regenerative Potential of Concentrated Platelet-Rich Fibrin: An In Vitro Study.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A new type of platelet concentrate used in regenerative periodontal therapy, called concentrated platelet-rich fibrin (C-PRF), contains more growth factors than previous generations of platelet concentrate. Compared to fixed-angle centrifugation, a recently discovered technique called horizontal centrifugation can produce C-PRF with a more evenly distributed quantity of platelets and improved biological properties. This study aims to determine the effect of horizontal and fixed-angle centrifugation methods on the release of transforming growth factor β1 (TGF-β1) and platelet-derived growth factor AB (PDGF-AB), as well as on the migration and proliferation of osteoblast cells. Materials and Methods: This study used two test groups: a horizontal group and a fixed-angle group. The release of growth factors TGF-β1 and PDGF-AB was measured at five time points: the first, third, seventh, 10 Results: The findings indicated a statistically significant increase in the release of TGF-β1 and PDGF-AB in the horizontal group compared to the fixed-angle group over a 14-day period. The horizontal group's TGF-β1 release increased by a factor of 1.5 compared to the fixed-angle group, peaking on day 7. Following a 24-hour incubation period and microscopic examination, the horizontal group exhibited greater osteoblast migratory activity than the control group and the fixed-angle centrifugation group. Horizontal centrifugation C-PRF had a significantly greater effect on osteoblast proliferation than fixed-angle centrifugation. The horizontal group's proliferation rate surpassed that of the fixed-angle group by up to 1.5 times on the third day of observation. Conclusion: Compared to fixed-angle centrifugation, the horizontal method of preparing C-PRF has a greater effect on the release of growth factors and the behavior of osteoblasts.
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Registered trials
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