Evidence map›Paper›PMID 41202817›Full record

ArticleStem cell reports2025

Modeling in vivo induction of gastric insulin-secreting cells using transplanted human stomach organoids.

Jiaqi Lu, Hyunkee Kim, Jian Zhu, Capucine Martin, Jiaoyue Zhang, Vasumati Polavarapu, Lauretta A Lacko, Chaiyaboot Ariyachet, Anna A Dattoli, Tao Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiaqi LuCenter for Drug Evaluation, National Medical Products Administration, Beijing 100076, China; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Hyunkee KimDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Jian ZhuDepartment of Endocrinology, Affiliated Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214122, China.
Capucine MartinDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Human Therapeutic Organoid Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.
Jiaoyue ZhangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Division of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, HuBei 430022, China.
Vasumati PolavarapuDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Lauretta A LackoDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Human Therapeutic Organoid Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.
Chaiyaboot AriyachetDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Anna A DattoliDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Tao LiuDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Xia ChenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Qing XiaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: xqing@hsc.pku.edu.cn.
Xiaofeng HuangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Division of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: xih4001@med.cornell.edu.
Qiao ZhouDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Division of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Human Therapeutic Organoid Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.

Funding

Derivation of pancreatic islet-like organoids from human gastric stem cellsR01DK133332 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2022 to 2025
$2.3M
NIDDK NIH HHS R01 DK133332
6 · The paper itself

Abstract

Insulin-dependent diabetes could be treated by supplying patients with primary pancreatic islets or other types of insulin-secreting cells. Functional insulin-secreting cells can be induced in situ from the murine stomach using defined genetic factors, offering a promising method to directly produce autologous insulin-secreting cells. Here, we modeled whether such gastric insulin-secreting (GINS) cells could be generated in vivo from human stomach tissues. We produced human gastric organoids (hGOs) from human embryonic stem cells engineered with inducible expression of reprogramming factors. The hGOs were stably transplanted for 6 months and showed robust cytodifferentiation resembling the human stomach in structure and cellular composition. Upon hGO maturation in vivo, we activated the reprogramming factors and observed the formation of insulin

Indexed as

Insulin-Secreting CellsOrganoidsStomachAnimalsCell DifferentiationCellular ReprogrammingDiabetes Mellitus, ExperimentalHuman Embryonic Stem CellsHumansInsulinMiceInsulinbeta cell replacementcell reprogrammingGINShuman insulin-secreting cellsorgan engineering for type 1 diabetesstomach-derived beta like cellstype 1 diabetes

Identifiers

PMID41202817
PMCPMC12744831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.