ReviewCancer cell2026
Cellular senescence in precancer lesions and early-stage cancers.
Abstract readReview
In one paragraph
Review in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Precancerous microenvironment: A signalling perspective.Current opinion in cell biology · 2026Review
- Dyskerin dysfunction in cancer development: from telomere dysregulation to immune deficiency.American journal of cancer research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Xen Ping HoiDepartment of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, USA.
Mary M StangisUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Sarah E GlassEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Gastroenterology, Hepatology, & Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jin-Hee KimTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Seung Woo KangEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
W Nathaniel BrennenDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ziyi LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
William M GradyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, USA.
Srinivasan YegnasubramanianDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Molecular Radiation Science Division, Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Peter KuhnConvergent Science Institute in Cancer, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Costas A LyssiotisDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Akiko SagaraLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
Martha J ShrubsoleVanderbilt-Ingram Cancer Center, Nashville, TN, USA; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Humam KadaraDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Ying YuanDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Robert J CoffeyEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Gastroenterology, Hepatology, & Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Ken S LauEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Nashville, TN, USA; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Angelo M De MarzoDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Anirban MaitraLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA; Department of Pathology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA; Department of Medicine, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
Jimin MinLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA; Department of Medicine, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA. Electronic address: jimin.min@nyulangone.org.
Ming YuTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address: myu@fredhutch.org.
Keith S ChanDepartment of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, USA. Electronic address: kschan@houstonmethodist.org.
TBEL Consortium
Funding
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6MUnderstanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiomeU54CA274374 · NCI · FRED HUTCHINSON CANCER CENTER · PI Neelendu Dey, William Mallory Grady · 2022 to 2026
$10.7MTraining in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4MThe stromal microenvironment as a co-organizer of bladder carcinogenesis and progressionU54CA274375 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Hideki Furuya · 2022 to 2026
$10.2MShaping the Microenvironment by DPEP1 Facilitates Adenoma ProgressionU54CA274367 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bhuminder Singh · 2022 to 2026
$9.7MTumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic CancerU54CA274371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIRBAN MAITRA, Marina Pasca Di Magliano · 2022 to 2026
$9.5MIntegrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4MTranslational imaging biomarkers of the tumor microenvironment in early prostate cancerU54CA274370 · NCI · JOHNS HOPKINS UNIVERSITY · PI Srinivasan Yegnasubramanian · 2022 to 2026
$9.1MIntegrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6MBiomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagusU2CCA271902 · NCI · FRED HUTCHINSON CANCER CENTER · PI William Mallory Grady, Cecilia C Yeung · 2022 to 2026
$5.3MPASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)U24CA274274 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI J. Jack LEE, ANIRBAN MAITRA · 2022 to 2026
$4.9MDistinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting ApproachesR01CA175397 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHAN, KEITH SYSON · 2013 to 2025
$4.8MNCI NIH HHS P50 CA236733NCI NIH HHS R01 CA175397NCI NIH HHS R01 CA255259NCI NIH HHS R01 CA289291NCI NIH HHS R35 CA197570NCI NIH HHS R50 CA233042NCI NIH HHS T32 CA009135NCI NIH HHS T32 CA119925NCI NIH HHS U24 CA274212NCI NIH HHS U24 CA274274NCI NIH HHS U2C CA271902NCI NIH HHS U54 CA274367NCI NIH HHS U54 CA274370NCI NIH HHS U54 CA274371NCI NIH HHS U54 CA274374NCI NIH HHS U54 CA274375NIA NIH HHS U01 AG077920NIDDK NIH HHS R01 DK103831
Abstract
Cellular senescence plays dual roles in precancer lesions: initially serving as a tumor-suppressive barrier within the epithelial compartment and later contributing to a pro-tumoral precancer tissue microenvironment (PreTME) via a sustained, paracrine secretome known as senescent-associated secretory phenotype (SASP). This commentary highlights the role of senescence across various PreTME cell types, explores emerging pharmacologic and lifestyle interception strategies, and outlines current challenges for advancing biomarkers and clinical translation.
Indexed as
Cellular SenescenceNeoplasmsPrecancerous ConditionsAnimalsHumansSenescence-Associated Secretory PhenotypeTumor Microenvironment
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.