Evidence map›Paper›PMID 41202796›Full record

ArticleStructure (London, England : 1993)2025

Serine encodes drug selectivity in human OAT1.

Yaxin Dai, Chia-Hsueh Lee

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yaxin DaiDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chia-Hsueh LeeDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: chiahsueh.lee@stjude.org.

Funding

Structural and functional investigations on synaptic vesicular transportersR01NS133147 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Chia-Hsueh Lee · 2024 to 2026
$1.6M
NINDS NIH HHS R01 NS133147
6 · The paper itself

Abstract

Why do certain drugs bind human OAT1 with much higher affinity than the rat ortholog? In this issue of Structure, Jeon et al.

Indexed as

ImidazolesOrganic Anion Transport Protein 1SerineTetrazolesAnimalsBinding SitesChloridesHumansProtein BindingRatsChloridesImidazolesolmesartanOrganic Anion Transport Protein 1SerineTetrazoles

Identifiers

PMID41202796
PMCPMC12826767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.