ArticleAnais brasileiros de dermatologia
Histological and immunohistochemical findings in recurrent nevi.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRecurrent nevi (RN) arise from the incomplete removal of a benign melanocytic lesion. They may present with clinical and dermoscopic characteristics similar to melanomas and are a potential mimic of neoplasia.
objectiveTo describe histopathological and immunohistochemical findings of recurrent nevi, including BRAF immunoexpression.
methodsA cross-sectional study was conducted on 58 recurrent nevi obtained from a previous prospective study. RN were submitted to histopathological and immunohistochemical analysis. The markers HMB-45, Tyrosinase, Ki-67, and BRAF V-600E were used.
resultsA trizonal pattern was observed in 84.5% of cases and is defined by the presence of junctional melanocytic proliferation, scar tissue, and residual dermal nests. Furthermore, architectural asymmetry (56.9%), lentiginous hyperplasia (75.9%), fibrosis (98.4%), lymphocytic infiltrate (96.5%), and melanophages (79.2%) were identified. Dropping off was observed in 1.7%, adnexal involvement in 22.3%, a pagetoid distribution in 30%, and cell atypia in 15%. HMB-45 and tyrosinase were expressed in a gradient and were identified in 98.3% and 91.4%, respectively. Ki-67 was positive in all cases, and the mean proliferative index was 2.83%. BRAF expression was positive in 72.4%. STUDY LIMITATIONS: Limited sample size, evaluation by a single dermatopathologist, targeted immunohistochemical profiling, and the lack of red counterstaining could be potential limitations of the study.
conclusionsRN are characterized by architectural asymmetry and a trizonal pattern. Nuclear atypia and a pagetoid distribution may be observed. RN cells have a low proliferative index and are positive for HMB-45 and tyrosinase. BRAF expression occurs in most recurrences and is heterogeneous in RN melanocytes.
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