Evidence map›Paper›PMID 41202135›Full record

ArticleScience advances2025

Dynamically autofocused 3D pulsed laser micromachining enables advanced 3D bioelectronics.

Massimo Mariello, Joseph G Troughton, Yixuan Leng, Ziming Wang, Nuzli Karam, Lawrence Coles, José González-Martínez, Kawsar Ali, Daniel J Rogers, Madeline Lancaster and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Massimo MarielloInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.ORCID 0000-0002-2750-0422
Joseph G TroughtonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.ORCID 0000-0002-9419-9326
Yixuan LengInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.ORCID 0009-0005-5299-0485
Ziming WangInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.ORCID 0009-0003-5989-7334
Nuzli KaramDepartment of Electrical Engineering, University of Cambridge, Trumpington Street, CB2 1PZ Cambridge, UK.ORCID 0009-0000-4026-966X
Lawrence ColesInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.
José González-MartínezMedical Research Council (MRC) Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-3850-6803
Kawsar AliDepartment of Engineering Science, University of Oxford, OX1 3PJ Oxford, UK.ORCID 0000-0002-2777-3957
Daniel J RogersDepartment of Engineering Science, University of Oxford, OX1 3PJ Oxford, UK.ORCID 0000-0001-8814-5332
Madeline LancasterMedical Research Council (MRC) Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-2324-8853
Christopher M ProctorInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ Oxford, UK.ORCID 0000-0002-2066-1354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancing next-generation bioelectronic interfaces requires devices that are soft, miniaturized, and seamlessly integrated with biological tissues. However, conventional fabrication methods, primarily based on UV photolithography, struggle to meet these needs, relying on hazardous chemicals, labor-intensive processes, and planar, layer-by-layer construction. To overcome these limits, we introduce dynamically autofocused 3D pulsed laser micromachining (d-3DPLM) using a nanosecond pulsed near-infrared laser. This approach enables rapid, cost-effective structuring of diverse materials, including thin films, metal foils, and bulk metal blocks, supporting monolithic, multilayer bioelectronics with complex 3D architectures such as microneedles and deployable elements. d-3DPLM achieves high-resolution ablation and patterning for conformable and functional device geometries. Demonstrated applications include electro-haptic patches, in vitro multielectrode diagnostic arrays, and wireless contact lenses for red light therapy. By broadening the design and manufacturing landscape for bioelectronic systems, this versatile method paves the way for improved performance, unique functionality, and enhanced integration with living tissue.

Indexed as

ElectronicsLasersMicrotechnologyEquipment DesignHumans

Identifiers

PMID41202135
PMCPMC12594197

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.