ArticlePloS one2025
Sleep deprivation disrupts diurnal rhythmicity of gut microbiota and blood inflammatory cytokines in mice.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026Review
- Processed Diets and Food Additives Shape the Gut Microbiota and Chronic Disease Risk Across the Life Course-A Three-Layer Ecosystem Disruption Model (TLED) Model.Life (Basel, Switzerland) · 2026Review
- Integrative mechanisms and intervention targets of the microbiota-gut-brain axis in depressive disorders: advances across immune, endocrine, and central nervous system pathways.Frontiers in psychiatry · 2026Review
- The microbiota-gut-brain axis in postpartum depression: a review of microbial mechanisms and therapeutic potential.Frontiers in psychiatry · 2026Review
- Sishen wan modulates gut microbial and short-chain fatty-acid imbalances and ameliorates behavioral and inflammatory abnormalities in mice with chronic sleep deprivation.Frontiers in microbiology · 2026Article
- Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.Frontiers in neurologyReview
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisruption of diurnal rhythms can lead to various diseases in humans and animals. There is an interaction between the diurnal rhythms of host and gut microbiota. This study was designed to determine whether sleep deprivation disrupted the diurnal rhythmicity of microbiota in the ileum, blood inflammatory cytokines and blood short chain fatty acids (SCFAs). SCFAs are products of gut microbiota.
methodsSix- to eight-week old CD1 male mice were sleep-deprived for 24 h by placing them in a small platform in a water tank. Their blood and ileal samples were harvested every 4 h in the next day. Mice with or without sleep deprivation were subjected to open field test.
resultsMice with sleep deprivation had decreased richness and altered taxonomic composition of microbiota in the ileum compared with controls. Sleep deprivation disrupted the diurnal rhythmicity of gut microbiota and blood inflammatory cytokines. Mice with sleep deprivation had higher cytokine concentrations (for example, interleukin 1β concentrations at Zeitgeber time 21 were 8.4 ± 0.9 and 5.4 ± 0.4 pg/ml for sleep deprivation and control groups, respectively, P = 0.0128) and were more anxious as assessed by open field test than control mice. Sleep deprivation did not affect the concentrations of SCFAs in the blood.
conclusionsOur results suggest that there are diurnal rhythms in the microbiota of ileum and blood inflammatory cytokines. Sleep deprivation disrupts these rhythms. Considering the known broad actions of inflammation, the increased inflammatory cytokines may mediate various biological effects, such as anxiety, of sleep deprivation.
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