SynthesisObesity facts2025
Transition of Care for Adolescents and Young Adults Living with Obesity: A Systematic Review with Indirect Evidence from Conditions Deemed Being Transferable.
Synthesis in Obesity facts, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
introductionAdolescence and early adulthood represent a critical phase for management of chronic diseases, including obesity. To improve transition of care in adolescents and young adults with obesity (AYALwO), the main goal was to summarize the current evidence on transition of care interventions (T-interventions) for obesity management. Anticipating a lack of evidence on T-interventions for AYALwO, we expanded the patient population to include individuals with other chronic diseases that can be appropriately transferred, such as diabetes.
methodsWe searched three databases and one trial registry from 01/2013 to 07/2025 and screened reference lists of included trials, i.e., randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSI) enrolling AYALwO, type 1 diabetes (T1D)/2, and RCTs only for inflammatory bowel disease (IBD), arthritis, or asthma (effects for these populations were considered transferable in case of lack of trials in AYALwO). We evaluated outcomes of T-interventions, e.g., glycated hemoglobin (HbA1c), quality of life, self-management, or transition readiness. The review process was completed by two reviewers independently. Results were synthesized via random-effects meta-analysis or descriptively.
resultsWe included 14 RCTs (n = 9 T1D, n = 2 mixed population, n = 1 IBD, n = 1 arthritis, n = 1 asthma) and 4 NRSI (n = 2 T1D, n = 2 mixed population). Prespecified outcomes were mostly reported infrequently and/or heterogeneously. Effect measures were mostly inconclusive or not meaningful. No effect was shown for HbA1c in seven RCTs (mean difference 0.12% [95% confidence interval -0.59; 0.83]) or in two NRSI. A higher transfer rate by appointment reminders (one RCT) or consultation at the same physician for pediatric and adult care (one RCT) and an improvement of transition readiness for transition-oriented patient education programs (one RCT, one NRSI) were found. Certainty of evidence (CoE) was very low for all outcomes, mainly due to a high risk of bias, indirectness, and imprecision.
conclusionWe found no trial for AYALwO. Evidence on other chronic diseases was limited, showing that T-interventions lead to improvements in transfer rate or transition readiness (very low CoE). This highlights the need for future research regarding T-interventions in AYALwO.
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