ArticleActa crystallographica Section B, Structural science, crystal engineering and materials2025
The glycolipid flocculosin-A from the fungus Anthracocystis flocculosa, or how to deal with cotton-wool-like crystals.
Article in Acta crystallographica Section B, Structural science, crystal engineering and materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Flocculosin A is a strong antifungal metabolite secreted by the Basidiomycota fungus Anthracocystis flocculosa (formerly Pseudozyma flocculosa). It crystallizes in the form of long, soft cotton-wool-like needles, usually observed together with the mycelium in liquid culture conditions. Many crystallization tests were carried out. Among them, only a very slow cooling technique was able to yield suitable crystals, which were needle-like with a maximum thickness of 5 µm and several millimetres long. These crystals permitted us to record single-crystal X-ray diffraction data and solve the crystal structure as well as to determine the absolute configurations of the three chiral centres present in the two lipid chains.
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