Evidence map›Paper›PMID 41201920›Full record

ArticleNeoplasia (New York, N.Y.)2025

Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.

Shivani Soni, Pooja Mittal, Jae Ho Lo, Yan Yang, Goar Smbatyan, Keehoon Lee, Junxiang Wan, Hiroshi Kumagai, Kelvin Yen, Hemal H Mehta and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shivani SoniNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Pooja MittalNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jae Ho LoNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yan YangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Goar SmbatyanNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Keehoon LeeTranslational Genomics Research Institute (TGen North), part of City of Hope, Flagstaff, AZ, USA.
Junxiang WanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hiroshi KumagaiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kelvin YenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hemal H MehtaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Brendan MillerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Lesly Torres-GonzalezNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Francesca BattaglinNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Unnati Hemant ShahNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michela BartoliniNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Wu ZhangNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David W CraigDepartment of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Josh MillsteinDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Heinz-Josef LenzNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: lenz@usc.edu.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Metformin-Regulated Mitochondrial Peptides and their Effects on AgingR01AG069698 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2020 to 2024
$2.1M
NCI NIH HHS P30 CA014089NIA NIH HHS R01 AG069698
6 · The paper itself

Abstract

Colorectal Cancer (CRC) is the third most prevalent malignancy, leading to significant morbidity and mortality globally. Epidemiological studies suggest that chronological age and diet are among the major contributing factors correlated with the incidence of CRC. Our study aimed to provide insights into the association between age, diet, and gut microbiome in CRC using molecular techniques including RNA sequencing, cytokine analysis, and metagenomic analysis. We used syngeneic MC38 mice model divided into two age groups (old and young) and three diet groups (standard chow, calorie-restricted and high-fat). The major findings of this study are that age and diet impact intratumoral gene signaling (nuclear and mitochondrial), and hub genes we identified are associated with prognosis in CRC. Fecal microbiome analysis showed that old microbiomes have higher alpha diversity compared to young mice. Our results demonstrate that interactions between host (age) and external (diet) factors regulate tumor growth mediated by cytokines, mitochondrial derived proteins, and the gut microbiome. Collectively, our findings advance current understanding of the mechanisms by which aging, diet and gut microbiota impact CRC onset and progression though further investigation is warranted.

Indexed as

AgingColorectal NeoplasmsDietGastrointestinal MicrobiomeGene Expression Regulation, NeoplasticTumor MicroenvironmentAge FactorsAnimalsDisease Models, AnimalHumansMaleMiceCalorie restrictionColorectal cancerCytokinesInflammationMicrobiomeMitochondrial derived proteins

Identifiers

PMID41201920
PMCPMC12596543

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.