ReviewKidney3602026
Troubleshooting Ionized Hypocalcemia in Patients on Continuous KRT with Regional Citrate Anticoagulation.
Review in Kidney360, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional citrate anticoagulation (RCA) is the preferred anticoagulation method in continuous KRT (CKRT), provided its use is feasible without causing excessive systemic citrate accumulation. One significant concern with RCA is ionized hypocalcemia related to the CKRT procedure. This condition can arise from two primary causes: systemic citrate accumulation or net calcium loss from plasma. Systemic citrate accumulation occurs when the citrate load in the CKRT return blood exceeds the body's ability to metabolize it. On the other hand, net calcium loss occurs when calcium lost through the hemofilter and from the extracellular fluid space (due to tissue sequestration) exceeds the administered calcium supplementation. This case-based review outlines RCA-associated hypocalcemia and provides a framework for its evaluation and management at the bedside.
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