Evidence map›Paper›PMID 41201773›Full record

ArticleGeroScience2026

Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States.

Hye-Ji Seo, Yoosoo Chang, Seungho Ryu, Kyeezu Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hye-Ji SeoDepartment of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Yoosoo ChangCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, South Korea. yoosoo.chang@gmail.com.
Seungho RyuCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, South Korea.
Kyeezu KimDepartment of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea. kyeezu.kim@skku.edu.ORCID http://orcid.org/0000-0002-9094-9011

Funding

National Research Foundation of Korea RS-2024-00405650National Research Foundation of Korea (NRF) RS-2024-00333941
6 · The paper itself

Abstract

Muscle mass and strength influence various age-related health outcomes, however their individual and joint associations with biological aging remain understudied. This study investigated the associations of muscle health with epigenetic aging based on DNA methylation in blood samples, among middle-aged and older adults. We analyzed data from 1,121 individuals from the 1999-2002 cycles of the National Health and Nutrition Examination Survey. Muscle mass was assessed using the appendicular skeletal muscle mass index, with low muscle mass defined as < 7.0 kg/m

Indexed as

AgingEpigenesis, GeneticMuscle, SkeletalMuscle StrengthAgedDNA MethylationFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesBiological agingEpigenetic ageMuscle massMuscle strength

Identifiers

PMID41201773
PMCPMC13575072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.