ArticleArchives of pharmacal research2025
Salvianolic acid A enhances T
Jiayang Wu, Kui Liu, Jinqian Song, Lihua Huang, Jiahong Gao, Fei Li, Tao Pang
Abstract read
In one paragraphArticle in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Jiayang WuState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Kui LiuState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Jinqian SongState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Lihua HuangState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Jiahong GaoState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Fei LiState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. lifei@cpu.edu.cn.ORCID http://orcid.org/0000-0001-8721-5183 Tao PangState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. tpang@cpu.edu.cn.ORCID http://orcid.org/0000-0001-5420-2060 Funding
National Natural Science Foundation of China 81973512National Natural Science Foundation of China 82174010National Natural Science Foundation of China 82322072
6 · The paper itselfAbstract
Salvianolic acid A (SAA), a major water-soluble bioactive compound extracted from Salvia miltiorrhiza, has been extensively studied for its diverse pharmacological properties in cerebrovascular diseases. However, its immunomodulatory effects on lymphocytes in stroke remain incompletely understood. This study systematically investigated the therapeutic efficacy and underlying mechanisms of SAA in a murine model of transient middle cerebral artery occlusion (tMCAO). Early administration of SAA (20 mg/kg) to ischemic stroke (IS) mice demonstrated neuroprotective effects, characterized by reduced infarct volume and improved behavioral outcomes, alongside creating a T
Indexed as
Caffeic AcidsImmunologic FactorsIschemic StrokeLactatesNeuroprotective AgentsT-Lymphocytes, RegulatoryAnimalsCore Binding Factor Alpha 2 SubunitDisease Models, AnimalForkhead Transcription FactorsInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLCaffeic AcidsCore Binding Factor Alpha 2 SubunitForkhead Transcription FactorsFoxp3 protein, mouseImmunologic FactorsLactatesNeuroprotective Agentssalvianolic acid AImmunomodulatorIschemic strokeRUNX1/CBFβ complexSalvianolic acid ATreg cells
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