ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Short course of antimicrobial treatment for uncomplicated enterococcal bacteremia.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Oral transition therapy versus intravenous therapy for the treatment of uncomplicated Enterococcal bloodstream infections.Infection · 2026Article
- Article
- Outcomes of early oral antibiotic transition for the treatment of uncomplicated enterococcal bacteremia.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDuration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18 days).
methodsThis retrospective study was conducted at the Lausanne University Hospital, Switzerland (January 2015-June 2024) and included adult patients with uncomplicated enterococcal bacteremia. Primary outcome was a composite of mortality, recurrence of bacteremia by the same enterococcal species and development of bone and joint infection within 120 days.
resultsDuring the study period, 331 episodes of uncomplicated enterococcal bacteremia were included. The median duration of antimicrobial treatment was 12 days (interquartile range: 8-15); 138 (42%) and 193 (58%) episodes received a short (4-10 days) and long (11-18 days) duration of antimicrobial treatment, respectively. The primary endpoint was observed in 77 (23%) episodes; 120-day mortality was 21% (69 episodes), recurrence of bacteremia was 4% (12 episodes), and bone and joint infection was 0.6% (2 episodes). No difference in primary endpoint was observed between episodes receiving short and long courses of antimicrobial treatment (23% versus 23%; P = 1.000). The Cox multivariable regression model found that malignancy (aHR 2.00, 95% CI 1.24-3.22), immunosuppression (1.78, 1.09-2.90), cirrhosis (2.53, 1.42-4.51), and sepsis or septic shock (2.48, 1.52-4.03) were associated with primary endpoint; a short course of antimicrobial treatment was not associated with primary endpoint (1.03, 0.65-1.62).
conclusionAmong uncomplicated enterococcal bacteremia giving a short duration of antimicrobial treatment is reasonable.
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