Evidence map›Paper›PMID 41201686›Full record

ArticleApplied biochemistry and biotechnology2026

Phycobiliproteins of Marine Red Alga, Kappaphycus Alvarezii Possess Potent Antioxidant and Metal Chelating Properties, and Inhibit Hepatocellular Carcinoma (HepG2) Cell Growth.

Gayathridevi Mahendran, Nimish Mol Stephen, Mangaiyarkarasi Manivel, Tehreem Maradagi, Muralidharan Nagarajan, Jayakumar Natarajan, Ganesan Ponesakki

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gayathridevi MahendranDepartment of Fish Processing Technology, Dr.M.G.R Fisheries College and Research Institute, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Ponneri, Tamil Nadu, 601 204, India.
Nimish Mol StephenDepartment of Fish Processing Technology, Dr.M.G.R Fisheries College and Research Institute, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Ponneri, Tamil Nadu, 601 204, India. nimish@tnfu.ac.in.ORCID http://orcid.org/0000-0002-3229-5101
Mangaiyarkarasi ManivelDepartment of Fish Processing Technology, Dr.M.G.R Fisheries College and Research Institute, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Ponneri, Tamil Nadu, 601 204, India.
Tehreem MaradagiDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute (CFTRI), Mysuru, 570 020, Karnataka, India.
Muralidharan NagarajanDepartment of Fish Processing Technology, Dr.M.G.R Fisheries College and Research Institute, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Ponneri, Tamil Nadu, 601 204, India.
Jayakumar NatarajanDepartment of Fisheries Biology and Resource Management, Dr.M.G.R Fisheries College and Research Institute, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Ponneri, Tamil Nadu, 601 204, India.
Ganesan PonesakkiDepartment of Biochemistry and Biotechnology, CSIR-Central Leather Research Institute (CLRI), Adyar, Chennai, Tamil Nadu, 600 020, India.

Funding

TNSCST TNSCST
6 · The paper itself

Abstract

Kappaphycus alvarezii is one of the economically important red alga, harvested primarily for the production of hydrocolloids. This study aimed to identify an effective extraction method for the isolation of phycobiliproteins (PBPs) from K. alvarezii and evaluate its biofunctional properties. Organic solvents, inorganic acids, organic acids, phosphate buffer saline (PBS), distilled water, and freeze-thawing were used to identify an effective extraction method. The identification of PBPs was carried out by UV-Vis spectrophotometry, FTIR spectroscopy, and SDS-PAGE analysis. The antioxidant potentials of PBPs was examined by DPPH and ABTS radical scavenging assays. The metal chelating efficiency was determined using divalent, monovalent, and trivalent metal ions. The WST-1 assay and DAPI staining were performed to examine HepG2 cell viability and apoptosis, respectively. Among the extraction methods, higher content of phycoeryhrin was recorded in phosphate buffer saline. The results showed that extraction using PBS exhibits highest content of phycoerythrin. The PBPs fraction contains phycoerythrin as a major pigment molecule. The isolated PBPs exhibited increased DPPH and ABTS radical scavenging activity in a concentration-dependent manner. It has possible quenching ability of Co

Indexed as

AntioxidantsCarcinoma, HepatocellularChelating AgentsLiver NeoplasmsMetalsPhycobiliproteinsRhodophytaApoptosisCell ProliferationEdible SeaweedsHep G2 CellsHumansAntioxidantsChelating AgentsMetalsPhycobiliproteinsBio-functionalityExtraction methodsKappaphycus alvareziiMarine red algaeNutritional compositionPhycobiliproteins

Identifiers

PMID41201686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.