ArticleExperimental brain research2025
"The impact of aging on cognitive and motor functions: a molecular and behavioral study in female C57BL/6 mice".
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protective role of hemokinin-1 against age-dependent spatial memory and attention decline in mice.GeroScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Aging leads to various changes in nervous system functions. Older humans and animals exhibit altered movement patterns and experience alterations in memory and motor functions. Rodent models, particularly aged C57BL/6 mice, have been instrumental in studying behavioral and neurophysiological changes associated with aging. This study aimed to characterize age-related cognitive and motor decline and examine its association with molecular changes in a physiologically aged murine model. For this purpose, female C57BL/6Cenp mice aged 2, 20, and 26 months were used. Several behavioral tests were conducted to evaluate motor and cognitive functions. Additionally, gene expression levels were analyzed in prefrontal cortex and hippocampus samples. Twenty-month-old mice exhibited reduced muscle strength, altered gait patterns, impaired balance on the rotarod test, and deficits in spatial reference memory as assessed by the Barnes maze. Motor function further deteriorated in senescent mice (26-month-old), accompanied by spatial memory impairment as assessed using forced Y-maze test. Moreover, significant changes were observed in the expression of genes associated with synaptic plasticity (ARC, CREB1), neuronal activity (FOS), myelination (OLIG1, MAL), and oxidative stress (CYBA, CYBB, NCF1). These findings confirm that aging is a complex phenomenon marked by progressive cognitive and motor impairments, driven by molecular changes in brain regions involved in critical functions such as motor processes and cognition.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.