ArticleHead and neck pathology2025
Potential Diagnostic Pitfall in Pleomorphic Adenoma: A Case of Squamous and Mucinous Metaplasia with MALAT1::PLAG1 Fusion.
Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPleomorphic adenoma (PA) is the most common benign salivary gland tumor, yet its histologic diversity can resemble malignant neoplasms, posing diagnostic challenges. Molecular characterization, including fusion gene analysis, can aid in distinguishing these cases. CASE PRESENTATION: A 28-year-old male presented with a painless, well-circumscribed 2.5 cm left parotid mass. Imaging showed a lobulated lesion without lymphadenopathy. The patient underwent superficial parotidectomy. The resected mass was encapsulated and tan, with homogeneous consistency. Microscopic analysis revealed squamous and mucinous metaplasia within a typical pleomorphic adenoma background, initially raising concern for mucoepidermoid carcinoma. NGS identified a MALAT1::PLAG1 fusion, confirming the diagnosis of pleomorphic adenoma with squamous and mucinous metaplasia. The patient remains disease-free 21 months postoperatively. This represents only the second reported case of a MALAT1::PLAG1 fusion in pleomorphic adenoma.
conclusionThis case highlights a rare molecular subtype of pleomorphic adenoma associated with the MALAT1::PLAG1 fusion. The presence of this fusion may underlie metaplastic differentiation and mimic malignancy. Recognition of such molecular events is crucial for accurate diagnosis and underscores the importance of integrating histopathology with genomic profiling in salivary gland tumor evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.